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Literature summary for 2.4.1.17 extracted from
- Glucuronidation of curcuminoids by human microsomal and recombinant UDP-glucuronosyltransferases (2007), Mol. Nutr. Food Res., 51, 932-938.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of several human isozymes in Spodoptera frugiperda Sf9 cells using the baculovirus transfection method | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.17 | - |
propofol | pH 7.5, 37°C, isozyme UGT1A9 | Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | The phenolic glucuronidation of the curcuminoids is predominantly catalyzed by hepatic isozyme UGT1A1 and intestinal isozymes UGT1A8 and UGT1A10, whereas isozymes UGT1A9, UGT2B7, and UGT1A8 exhibit high activities for hexahydro-curcuminoids, substrate specificities of recombinant isozymes in insect cell microsomes, overview | ? | - |
? | |
| UDP-D-glucuronate + acceptor | Homo sapiens | glucuronidation is a major phase II conjugation reaction of numerous xenobiotic as well as endobiotic compounds | UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + bisdemethoxy-curcumin | Homo sapiens | - |
UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide | - |
? | |
| UDP-D-glucuronate + curcumin | Homo sapiens | glucuronidation is an important pathway in the metabolism of curcumin | UDP + curcumin phenolic beta-D-monoglucuronide | - |
? | |
| UDP-D-glucuronate + demethoxy-curcumin | Homo sapiens | - |
UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| intestine | - |
Homo sapiens | - |
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.000045 | - |
substrate curcumin in liver microsomes | Homo sapiens |
| 0.000128 | - |
substrate propofol in liver microsomes | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | The phenolic glucuronidation of the curcuminoids is predominantly catalyzed by hepatic isozyme UGT1A1 and intestinal isozymes UGT1A8 and UGT1A10, whereas isozymes UGT1A9, UGT2B7, and UGT1A8 exhibit high activities for hexahydro-curcuminoids, substrate specificities of recombinant isozymes in insect cell microsomes, overview | Homo sapiens | ? | - |
? | |
| UDP-D-glucuronate + 17beta-estradiol | - |
Homo sapiens | UDP + 17beta-estradiol-3-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + 4-(trifluoromethyl)-umbelliferone | - |
Homo sapiens | UDP + 4-(trifluoromethyl)-umbelliferone beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + acceptor | glucuronidation is a major phase II conjugation reaction of numerous xenobiotic as well as endobiotic compounds | Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + bisdemethoxy-curcumin | - |
Homo sapiens | UDP + bisdemethoxy-curcumin phenolic beta-D-monoglucuronide | - |
? | |
| UDP-D-glucuronate + curcumin | - |
Homo sapiens | UDP + curcumin phenolic beta-D-monoglucuronide | - |
? | |
| UDP-D-glucuronate + curcumin | glucuronidation is an important pathway in the metabolism of curcumin | Homo sapiens | UDP + curcumin phenolic beta-D-monoglucuronide | - |
? | |
| UDP-D-glucuronate + demethoxy-curcumin | - |
Homo sapiens | UDP + demethoxy-curcumin phenolic beta-D-monoglucuronide | - |
? | |
| UDP-D-glucuronate + propofol | - |
Homo sapiens | UDP + propofol beta-D-glucuronoside | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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