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Literature summary for 2.4.1.17 extracted from
- UDP-glucuronosyltransferase 2B15 (UGT2B15) and UGT2B17 enzymes are major determinants of the androgen response in prostate cancer LNCaP cells (2007), J. Biol. Chem., 282, 33466-33474.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| isozyme UGT2B15, sequence comparisons, realtime PCR expression analysis | Homo sapiens |
| isozyme UGT2B17, sequence comparisons, realtime PCR expression analysis | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | suppression of isozyme UGT2B15 by RNAsi leading to 70% reduction of the UGT mRNA levels and over 75% reduction of glucuronidation of androgens in prostate cancer LNCaP cells | Homo sapiens |
| additional information | suppression of isozyme UGT2B17 by RNAsi leading to 70% reduction of the UGT mRNA levels and over 75% reduction of glucuronidation of androgens in prostate cancer LNCaP cells | Homo sapiens |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens |  |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | ? | - |
? | |
| additional information | Homo sapiens | isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | ? | - |
? | |
| UDP-D-glucuronate + androstane-3alpha,17beta-diol | Homo sapiens | in epithelial cells of the human prostate | UDP + ? | - |
? | |
| UDP-D-glucuronate + androsterone | Homo sapiens | in epithelial cells of the human prostate | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + dihydrotestosterone | Homo sapiens | in epithelial cells of the human prostate | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O75795 | isozyme UGT2B17; isozyme UGT2B17 | - |
| Homo sapiens | P54855 | isozyme UGT2B15; isozyme UGT2B15 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| epithelial cell | - |
Homo sapiens | - |
| LNCaP cell | - |
Homo sapiens | - |
| prostate cancer cell | - |
Homo sapiens | - |
| prostate gland | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | isozyme UGT2B15 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | Homo sapiens | ? | - |
? | |
| additional information | isozyme UGT2B17 is a critical enzyme for the local inactivation of androgens and major determinants of the androgen response in prostate cancer LNCaP cells, overview | Homo sapiens | ? | - |
? | |
| UDP-D-glucuronate + androstane-3alpha,17beta-diol | - |
Homo sapiens | UDP + ? | - |
? | |
| UDP-D-glucuronate + androstane-3alpha,17beta-diol | in epithelial cells of the human prostate | Homo sapiens | UDP + ? | - |
? | |
| UDP-D-glucuronate + androsterone | - |
Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + androsterone | in epithelial cells of the human prostate | Homo sapiens | UDP + androsterone 3-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + dihydrotestosterone | - |
Homo sapiens | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + dihydrotestosterone | in epithelial cells of the human prostate | Homo sapiens | UDP + dihydrotestosterone 17-O-beta-D-glucuronoside | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase 2B15 | - |
Homo sapiens |
| UDP-glucuronosyltransferase 2B17 | - |
Homo sapiens |
| UGT2B15 | - |
Homo sapiens |
| UGT2B17 | - |
Homo sapiens |
| uridine diphosphate-glucuronosyltransferase 2 B15 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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Release 2023.1 (January 2023)
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