Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | especially rifampicin, dexamethasone, and also omeprazole induce the expression of isozyme UGT1A1, and to a lesser extent of isozymes UGT1A6 and UGT1A9, overview | Macaca fascicularis | |
additional information | rifampicin, dexamethasone, and especially omeprazole induce the expression of isozyme UGT1A1, and to a much lesser extent of isozymes UGT1A6 and UGT1A9, overview | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
DNA and amino acid sequence determination, realtime RT-PCR analysis | Macaca fascicularis |
realtime RT-PCR analysis | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
microsome | - |
Macaca fascicularis | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | Macaca fascicularis | - |
UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
female and male Caucasians | - |
Macaca fascicularis | Q9TSL7 | isozyme UGT1A1; female and male cynomolgus monkeys | - |
Macaca fascicularis | Q9TSL9 | isozyme UGT1A6; female and male cynomolgus monkeys | - |
Macaca fascicularis | Q9TSM0 | isozyme UGT1A9; female and male cynomolgus monkeys | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
hepatocyte | primary culture | Homo sapiens | - |
hepatocyte | primary culture | Macaca fascicularis | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
UDP-D-glucuronate + acceptor | - |
Macaca fascicularis | UDP + acceptor beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase | - |
Homo sapiens |
UDP-glucuronosyltransferase | - |
Macaca fascicularis |