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Literature summary for 2.4.1.17 extracted from
- The albumin effect and drug glucuronidation: bovine serum albumin and fatty acid-free human serum albumin enhance the glucuronidation of UDP-glucuronosyltransferase (UGT) 1A9 substrates but not UGT1A1 and UGT1A6 activities (2008), Drug Metab. Dispos., 36, 1056-1062.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bovine serum albumin | activates isozyme UGT1A9 by reducing the Km of the substrates, overview | Homo sapiens | |
| fatty acid-free human serum albumin | activates isozyme UGT1A9 by reducing the Km of the substrates, overview | Homo sapiens | |
| additional information | no activation by human serum albumin | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of isozymes UGT1A1, UGT1A6, and UGT1A9 in HEK-293 cells | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| long-chain unsaturated fatty acids | selective inhibition of some UGT isozymes | Homo sapiens |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Homo sapiens | |
| 0.0029 | - |
4-Methylumbelliferone | pH 7.4, 37°C, isozyme UGT1A9 in presence of 2% fatty acid-free human serum albumin | Homo sapiens |  |
| 0.0072 | - |
propofol | pH 7.4, 37°C, isozyme UGT1A9 in presence of 2% fatty acid-free human serum albumin | Homo sapiens | |
| 0.0106 | - |
propofol | pH 7.4, 37°C, liver microsomes in presence of 2% fatty acid-free human serum albumin | Homo sapiens | |
| 0.0134 | - |
4-Methylumbelliferone | pH 7.4, 37°C, isozyme UGT1A9 | Homo sapiens | |
| 0.041 | - |
propofol | pH 7.4, 37°C, isozyme UGT1A9 | Homo sapiens | |
| 0.127 | - |
propofol | pH 7.4, 37°C, liver microsomes | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-D-glucuronate + acceptor | Homo sapiens | - |
UDP + acceptor beta-D-glucuronoside | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | O60656 | isozymes UGT1A1, UGT1A6, and UGT1A9 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-D-glucuronate + 4-methylumbelliferone | - |
Homo sapiens | UDP + 4-methylumbelliferyl beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + acceptor | - |
Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? | |
| UDP-D-glucuronate + propofol | - |
Homo sapiens | UDP + propofol beta-D-glucuronoside | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UDP-glucuronosyltransferase 1A9 | - |
Homo sapiens |
| UGT1A9 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Homo sapiens |
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