Cloned (Comment) | Organism |
---|---|
recombinant UGT1A5, expressed in baculovirusinfected insect cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | replacing the first 110 amino acids of UGT1A5, a region that may be involved in substrate binding, with the counterpart segment from UGT1A4 does not increase the 4-aminobiphenyl glucuronidation activity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P35504 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Caco-2 cell | low-level UGT1A5 expression | Homo sapiens | - |
Hep-G2 cell | low-level UGT1A5 expression | Homo sapiens | - |
hepatocyte | a low basal level of UGT1A5 expression in cultured hepatocytes. Treatment with rifampicin or 3-methylcholanthrene increases the level of UGT1A5 mRNA | Homo sapiens | - |
intestine | UGT1A5 expression in various segments of the intestine, high interindividual variability in its level and distribution along the intestine | Homo sapiens | - |
liver | low-level UGT1A5 expression | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-hydroxypyrene + UDP-glucuronate | - |
Homo sapiens | ? | - |
? | |
4-methylumbelliferone + UDP-glucuronate | very low rate of glucuronidation | Homo sapiens | UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide | - |
? | |
additional information | no glucuronidation of 4-aminobiphenyl, a good substrate for the highly homologous enzymes UGT1A4 and UGT1A3 | Homo sapiens | ? | - |
? | |
scopoletin + UDP-glucuronate | very low rate of glucuronidation | Homo sapiens | UDP + scopoletin O-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 1A5 | - |
Homo sapiens |