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Literature summary for 2.4.1.17 extracted from

  • Basu, N.K.; Ciotti, M.; Hwang, M.S.; Kole, L.; Mitra, P.S.; Cho, J.W.; Owens, I.S.
    Differential and special properties of the major human UGT1-encoded gastrointestinal UDP-glucuronosyltransferases enhance potential to control chemical uptake (2004), J. Biol. Chem., 279, 1429-1441.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
expression of isozymes in COS-1 cells Homo sapiens
expression of isozymes in COS-1 cells, DNA sequence determination and analysis of isozyme UGT1A9 Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
curcumin
-
 Homo sapiens
nordihydroguaiaretic acid
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens
additional information
-
 additional information kinetics, different isozymes, pH-values, and substrates Homo sapiens
0.004
-
 chrysin isozyme UGT1A1, pH 7.6, 37°C Homo sapiens
0.005
-
 chrysin isozyme UGT1A1, pH 6.4, 37°C Homo sapiens
0.0068
-
 phloretin isozyme UGT1A8, pH 7.0, 37°C Homo sapiens
0.0084
-
 eugenol isozyme UGT1A10, pH 7.6, 37°C Homo sapiens
0.01
-
 anthraflavic acid isozyme UGT1A1, pH 6.4 or pH 7.6, 37°C Homo sapiens
0.01
-
 anthraflavic acid isozyme UGT1A9, pH 7.6, 37°C Homo sapiens
0.0159
-
 eugenol isozyme UGT1A7, pH 6.4, 37°C Homo sapiens
0.0245
-
 eugenol isozyme UGT1A10, pH 6.4, 37°C Homo sapiens
0.0257
-
 eugenol isozyme UGT1A7, pH 8.5, 37°C Homo sapiens
0.045
-
 phloretin isozyme UGT1A10, pH 6.4, 37°C Homo sapiens
0.0964
-
 phloretin isozyme UGT1A7, pH 6.4, 37°C Homo sapiens
0.1
-
 curcumin isozyme UGT1A1, pH 6.4, 37°C Homo sapiens
0.1
-
 curcumin isozyme UGT1A7, pH 7.6, 37°C Homo sapiens
0.1
-
 curcumin isozyme UGT1A8, pH 7.0, 37°C Homo sapiens
0.1
-
 curcumin isozymes UGT1A1 and UGT1A10, pH 6.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens O60656 isozyme UGT1A9
-
Homo sapiens P22309 isozyme UGT1A1
-
Homo sapiens Q9HAW7 isozyme UGT1A7
-
Homo sapiens Q9HAW9 isozyme UGT1A8
-

Source Tissue

Source Tissue Comment Organism Textmining
adrenal gland isozyme UGT1A7 Homo sapiens
-
bone marrow isozyme UGT1A8 Homo sapiens
-
colon isozyme UGT1A9 Homo sapiens
-
epithelium mucosal epithelial layer of the gastrointestinal tract Homo sapiens
-
gastrointestinal tract
-
 Homo sapiens
-
ileum isozyme UGT1A1 Homo sapiens
-
jejunum isozyme UGT1A1 Homo sapiens
-
jejunum isozymes UGT1A9 Homo sapiens
-
jejunum isozymes UGT1A9 and UGT1A1 Homo sapiens
-
kidney isozyme UGT1A9 Homo sapiens
-
liver isozyme UGT1A1 Homo sapiens
-
additional information tissue distribution and expression patterns of isozymes UGT1A1, and UGT1A7-10 Homo sapiens
-
additional information tissue distribution and expression patterns of isozymes, overview Homo sapiens
-
mucosa mucosal epithelial layer of the gastrointestinal tract Homo sapiens
-
rectum isozyme UGT1A9 Homo sapiens
-
stomach isozyme UGT1A7 Homo sapiens
-
stomach isozyme UGT1A8 Homo sapiens
-
stomach isozymes UGT1A7 and UGT1A8 Homo sapiens
-
thyroid gland isozyme UGT1A7 Homo sapiens
-
uterus isozyme UGT1A1 Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 substrate specificities of isozymes Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isozymes are involved in detoxification of metabolites, drugs, toxins, and environmental chemicals via conjugation to glucuronic acid, physiological roles and overlapping activities Homo sapiens ?
-
 ?
additional information substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone isozyme UGT1A1 Homo sapiens ?
-
 ?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone isozyme UGT1A7 Homo sapiens ?
-
 ?
UDP-glucuronate + 2',4,4',6'-tetrahydroxychalcone isozymes UGT1A1, UGT1A7, and UGT1A10 Homo sapiens ?
-
 ?
UDP-glucuronate + Aloe-emodin isozyme UGT1A7 Homo sapiens UDP + Aloe-emodin beta-D-glucuronide
-
 ?
UDP-glucuronate + anthraflavic acid isozyme UGT1A1 Homo sapiens UDP + anthraflavic acid 2-O-beta-D-glucuronide
-
 ?
UDP-glucuronate + anthraflavic acid isozyme UGT1A9 Homo sapiens UDP + anthraflavic acid 2-O-beta-D-glucuronide
-
 ?
UDP-glucuronate + anthraflavic acid isozymes UGT1A1, and UGT1A9 Homo sapiens UDP + anthraflavic acid 2-O-beta-D-glucuronide
-
 ?
UDP-glucuronate + apigenin isozyme UGT1A1 Homo sapiens UDP + apigenin beta-D-glucuronide
-
 ?
UDP-glucuronate + apigenin isozyme UGT1A7 Homo sapiens UDP + apigenin beta-D-glucuronide
-
 ?
UDP-glucuronate + apigenin isozymes UGT1A1, UGT1A7, and UGT1A10 Homo sapiens UDP + apigenin beta-D-glucuronide
-
 ?
UDP-glucuronate + biochanin A isozyme UGT1A1 Homo sapiens UDP + biochanin A beta-D-glucuronide
-
 ?
UDP-glucuronate + biochanin A isozyme UGT1A7 Homo sapiens UDP + biochanin A beta-D-glucuronide
-
 ?
UDP-glucuronate + biochanin A isozymes UGT1A1, UGT1A7, and UGT1A10 Homo sapiens UDP + biochanin A beta-D-glucuronide
-
 ?
UDP-glucuronate + capsaicin isozyme UGT1A1 Homo sapiens UDP + capsaicin beta-D-glucuronide
-
 ?
UDP-glucuronate + capsaicin isozyme UGT1A7 Homo sapiens UDP + capsaicin beta-D-glucuronide
-
 ?
UDP-glucuronate + capsaicin isozymes UGT1A1, UGT1A7, and UGT1A10 Homo sapiens UDP + capsaicin beta-D-glucuronide
-
 ?
UDP-glucuronate + chrysin isozyme UGT1A1 Homo sapiens UDP + chrysin beta-D-glucuronide
-
 ?
UDP-glucuronate + chrysin isozyme UGT1A7 Homo sapiens UDP + chrysin beta-D-glucuronide
-
 ?
UDP-glucuronate + chrysin isozyme UGT1A8 Homo sapiens UDP + chrysin beta-D-glucuronide
-
 ?
UDP-glucuronate + chrysin isozyme UGT1A9 Homo sapiens UDP + chrysin beta-D-glucuronide
-
 ?
UDP-glucuronate + chrysin isozymes UGT1A1, UGT1A7, UGT1A8, UGT1A9, and UGT1A10 Homo sapiens UDP + chrysin beta-D-glucuronide
-
 ?
UDP-glucuronate + curcumin isozyme UGT1A1 Homo sapiens UDP + curcumin beta-D-glucuronide
-
 ?
UDP-glucuronate + curcumin isozyme UGT1A7 Homo sapiens UDP + curcumin beta-D-glucuronide
-
 ?
UDP-glucuronate + curcumin isozyme UGT1A8 Homo sapiens UDP + curcumin beta-D-glucuronide
-
 ?
UDP-glucuronate + curcumin isozymes UGT1A1, UGT1A7, UGT1A8, and UGT1A10 Homo sapiens UDP + curcumin beta-D-glucuronide
-
 ?
UDP-glucuronate + eugenol isozyme UGT1A7 Homo sapiens UDP + eugenol beta-D-glucuronide
-
 ?
UDP-glucuronate + eugenol isozymes UGT1A7, and UGT1A10 Homo sapiens UDP + eugenol beta-D-glucuronide
-
 ?
UDP-glucuronate + genistein isozyme UGT1A1 Homo sapiens UDP + genistein beta-D-glucuronide
-
 ?
UDP-glucuronate + genistein isozyme UGT1A7 Homo sapiens UDP + genistein beta-D-glucuronide
-
 ?
UDP-glucuronate + genistein isozymes UGT1A1, UGT1A7, and UGT1A10 Homo sapiens UDP + genistein beta-D-glucuronide
-
 ?
UDP-glucuronate + naringenin isozyme UGT1A1 Homo sapiens UDP + naringenin beta-D-glucuronide
-
 ?
UDP-glucuronate + naringenin isozyme UGT1A7 Homo sapiens UDP + naringenin beta-D-glucuronide
-
 ?
UDP-glucuronate + naringenin isozymes UGT1A1, UGT1A7, and UGT1A10 Homo sapiens UDP + naringenin beta-D-glucuronide
-
 ?
UDP-glucuronate + phloretin isozyme UGT1A7 Homo sapiens UDP + phloretin beta-D-glucuronide
-
 ?
UDP-glucuronate + phloretin isozyme UGT1A8 Homo sapiens UDP + phloretin beta-D-glucuronide
-
 ?
UDP-glucuronate + phloretin isozymes UGT1A7, UGT1A8, and UGT1A10 Homo sapiens UDP + phloretin beta-D-glucuronide
-
 ?
UDP-glucuronate + quercetin isozyme UGT1A1 Homo sapiens UDP + quercetin beta-D-glucuronide
-
 ?
UDP-glucuronate + quercetin isozyme UGT1A7 Homo sapiens UDP + quercetin beta-D-glucuronide
-
 ?
UDP-glucuronate + quercetin isozymes UGT1A1, UGT1A7, and UGT1A10 Homo sapiens UDP + quercetin beta-D-glucuronide
-
 ?
UDP-glucuronate + quinazarin isozyme UGT1A1 Homo sapiens UDP + quinazarin beta-D-glucuronide
-
 ?
UDP-glucuronate + quinazarin isozyme UGT1A7 Homo sapiens UDP + quinazarin beta-D-glucuronide
-
 ?
UDP-glucuronate + quinazarin isozymes UGT1A1, UGT1A7, and UGT1A10 Homo sapiens UDP + quinazarin beta-D-glucuronide
-
 ?
UDP-glucuronate + quinizarin isozyme UGT1A7 Homo sapiens UDP + quinizarin beta-D-glucuronide
-
 ?
UDP-glucuronate + thymol isozyme UGT1A7 Homo sapiens UDP + thymol beta-D-glucuronide
-
 ?
UDP-glucuronate + thymol isozymes UGT1A7, and UGT1A10 Homo sapiens UDP + thymol beta-D-glucuronide
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Homo sapiens
UGT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4 7.6 assay at Homo sapiens