Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.17 extracted from

  • Girard, C.; Barbier, O.; Veilleux, G.; El-Alfy, M.; Belanger, A.
    Human uridine diphosphate-glucuronosyltransferase UGT2B7 conjugates mineralocorticoid and glucocorticoid metabolites (2003), Endocrinology, 144, 2659-2668.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
stable expression in HEK293 cells, 2 allelic variants UGT2B7H268 and UGT2B7Y268 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information kinetics Homo sapiens
0.00023
-
 5alpha-dihydroaldosterone isozyme UGT2B7H268, pH 7.5, 37°C Homo sapiens
0.00036
-
 aldosterone isozyme UGT2B7Y268, pH 7.5, 37°C Homo sapiens
0.00036
-
 5alpha-dihydroaldosterone isozyme UGT2B7Y268, pH 7.5, 37°C Homo sapiens
0.00076
-
 aldosterone isozyme UGT2B7H268, pH 7.5, 37°C Homo sapiens
0.00197
-
 3alpha,5beta-tetrahydroaldosterone isozyme UGT2B7Y268, pH 7.5, 37°C Homo sapiens
0.0047
-
 3alpha,5beta-tetrahydroaldosterone isozyme UGT2B7H268, pH 7.5, 37°C Homo sapiens
0.0646
-
 5beta-tetrahydrocortisone isozyme UGT2B7H268, pH 7.5, 37°C Homo sapiens
0.0647
-
 5beta-tetrahydrocortisone isozyme UGT2B7Y268, pH 7.5, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens isozyme UGT2B7 is involved in metabolism of mineralocorticoid and glucocorticoid hormones, two-cell mechanism of aldosterone action and metabolism in the kidney ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16662 isozyme UGT2B7, 2 allelic variants UGT2B7H268 and UGT2B7Y268
-

Source Tissue

Source Tissue Comment Organism Textmining
epithelium of renal proximal tubules Homo sapiens
-
kidney isozyme UGT2B7 Homo sapiens
-
liver
-
 Homo sapiens
-
renal tubule proximal, epithelial cells Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 2 allelic variants UGT2B7H268 and UGT2B7Y268, the first being 11fold more effective in glucuronidation of aldosterone Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information isozyme UGT2B7 is involved in metabolism of mineralocorticoid and glucocorticoid hormones, two-cell mechanism of aldosterone action and metabolism in the kidney Homo sapiens ?
-
 ?
UDP-glucuronate + 3alpha,5beta-tetrahydroaldosterone high activity Homo sapiens UDP + 3alpha,5beta-tetrahydroaldosterone beta-D-glucuronide
-
 ?
UDP-glucuronate + 5alpha-dihydroaldosterone
-
 Homo sapiens UDP + 5alpha-dihydroaldosterone beta-D-glucuronide
-
 ?
UDP-glucuronate + 5alpha-tetrahydrocortisone
-
 Homo sapiens UDP + 5alpha-tetrahydrocortisone beta-D-glucuronide
-
 ?
UDP-glucuronate + 5beta-tetrahydrocortisone
-
 Homo sapiens UDP + 5beta-tetrahydrocortisone beta-D-glucuronide
-
 ?
UDP-glucuronate + aldosterone
-
 Homo sapiens UDP + aldosterone beta-D-glucuronide
-
 ?

Synonyms

Synonyms Comment Organism
UGT
-
 Homo sapiens
UGT2B7
-
 Homo sapiens
uridine diphosphate-glucuronosyltransferase
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens