Cloned (Comment) | Organism |
---|---|
expression of diverse isozymes in a lymphoblast expression system, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
5-hydroxytryptophol | competitive inhibition of serotonin glucuronidation | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.135 | - |
5-hydroxytryptophol | isozyme UGT1A6, pH 7.5, 37°C | Homo sapiens | |
3.674 | - |
5-hydroxytryptophol | isozyme UGT1A9, pH 7.5, 37°C | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P19224 | isozyme UGT1A6; isozymes UGT1A6 and UGT1A9 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activity of diverse recombinant isozymes with the different substrates | Homo sapiens |
0.0016 | - |
liver microsomes, substrate morphine 3-glucuronide | Homo sapiens |
0.0044 | - |
liver microsomes, substrate serotonin | Homo sapiens |
0.0052 | - |
liver microsomes, substrate N-acetylserotonin | Homo sapiens |
0.0072 | - |
liver microsomes, substrate 6-hydroxymelatonin | Homo sapiens |
0.008 | 4 | liver microsomes, substrate 5-hydroxytryptophol | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + 5-hydroxytryptophol | isozymes UGT1A6 and UGT1A9, the latter shows over 20fold lower activity | Homo sapiens | UDP + 5-hydroxytryptophol beta-D-glucuronide | - |
? | |
UDP-glucuronate + 6-hydroxymelatonin | - |
Homo sapiens | UDP + 6-hydroxymelatonin beta-D-glucuronide | - |
? | |
UDP-glucuronate + morphine 3-glucuronide | - |
Homo sapiens | UDP + ? | - |
? | |
UDP-glucuronate + N-acetylserotonin | - |
Homo sapiens | UDP + N-acetylserotonin beta-D-glucuronide | - |
? | |
UDP-glucuronate + serotonin | - |
Homo sapiens | UDP + serotonin beta-D-glucuronide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 1A6 | - |
Homo sapiens |
UGT1A6 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.2 | - |
5-hydroxytryptophol | isozyme UGT1A6, pH 7.5, 37°C | Homo sapiens | |
0.29 | - |
5-hydroxytryptophol | liver microsomes, pH 7.5, 37°C | Homo sapiens |