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Literature summary for 2.4.1.17 extracted from
- Evaluation of 3'-azido-3'-deoxythymidine, morphine, and codeine as probe substrates for UDP-glucuronosyltransferase 2B7 (UGT2B7) in human liver microsomes: specificity and influence of the UGT2B7*2 polymorphism (2003), Drug Metab. Dispos., 31, 1125-1133.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | kinetics, different isozymes | Homo sapiens | |
| 0.4 | - |
codeine | isozyme UGT2B7, pH 7.5, 37°C | Homo sapiens |  |
| 0.63 | - |
morphine | morphine 6-glucuronide formation, isozyme UGT2B7, pH 7.5, 37°C | Homo sapiens | |
| 0.67 | - |
morphine | morphine 3-glucuronide formation, isozyme UGT2B7, pH 7.5, 37°C | Homo sapiens | |
| 0.77 | - |
3'-azido-3'-deoxythymidine | isozyme UGT2B7, pH 7.5, 37°C | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | isozyme UGT2B7 is involved in glucuronidation of a wide array of clinically important drugs and endogenous compounds in humans | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
several isozymes | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
activities with morphine, codeine, and 3'-azido-3'-deoxythymidine of different isozymes | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | isozyme UGT2B7 is involved in glucuronidation of a wide array of clinically important drugs and endogenous compounds in humans | Homo sapiens | ? | - |
? | |
| additional information | the UGT2B7*2 polymorphism is not a determinant of glucuronodation specificity, substrate specificity by isozyme UGT2B7, overview | Homo sapiens | ? | - |
? | |
| UDP-glucuronate + 3'-azido-3'-deoxythymidine | isozymes UGT2B4, UGT2B7, and UGT2B17 | Homo sapiens | UDP + 3'-azido-3'-deoxythymidine beta-D-glucuronide | - |
? | |
| UDP-glucuronate + codeine | isozymes UGT2B4 and UGT2B7 | Homo sapiens | UDP + codeine beta-D-glucuronide | - |
? | |
| UDP-glucuronate + morphine | isozyme UGT2B7, low activity with isozymes UGT1A3, UGT1A10, UGT2B4 and UGT1A9 | Homo sapiens | UDP + morphine-3-beta-D-glucuronide | - |
? | |
| UDP-glucuronate + morphine | isozymes UGT2B4 and UGT2B7, low activity with isozymes UGT1A1, and UGT1A3 | Homo sapiens | UDP + morphine-6-beta-D-glucuronide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| More | enzyme belongs to the 2B subfamily | Homo sapiens |
| UDP-glucuronosyltransferase | - |
Homo sapiens |
| UDP-glucuronosyltransferase 2B7 | - |
Homo sapiens |
| UGT | - |
Homo sapiens |
| UGT2B7 | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | - |
assay at | Homo sapiens |
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