Cloned (Comment) | Organism |
---|---|
UGT1A71, UGT1a6 and UGT1A4 expressed in COS-1 cells | Oryctolagus cuniculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.037 | - |
imipramine | UGT1A41 | Oryctolagus cuniculus | |
0.14 | - |
imipramine | UGT1A71 | Oryctolagus cuniculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Oryctolagus cuniculus | - |
rabbit | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Oryctolagus cuniculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities of 14 substrates for UGTA1A7 and UGTA1A6 | Oryctolagus cuniculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
4-hydroxybiphenyl + UDPglucuronate | conjugated by UGT1A71 but not by UGT1A61 | Oryctolagus cuniculus | UDP + 4-hydroxybiphenyl 4-O-beta-D-glucuronide | - |
? | |
4-hydroxyestrone + UDP-glucuronate | conjugated by UGT1A71 but not by UGT1A61 | Oryctolagus cuniculus | UDP + 4-hydroxyestrone 4-O-glucuronide | - |
? | |
4-n-octylgallate + UDPglucuronate | highly specific for UGT1A71 | Oryctolagus cuniculus | UDP + 4-n-octylgallate 3-O-glucuronide | - |
? | |
4-nitrophenol + UDP-glucuronate | - |
Oryctolagus cuniculus | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
bilirubin + UDPglucuronate | UGT1A61: no activity | Oryctolagus cuniculus | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
estradiol-17beta + UDPglucuronate | UGT1A61 no activity | Oryctolagus cuniculus | estradiol-17beta-3-monoglucuronide + UDP | - |
? | |
estrone + UDPglucuronate | UGT1A61 inactive | Oryctolagus cuniculus | UDP + estrone 3-O-glucuronide | - |
? | |
imipramine + UDPglucuronate | conjugated by UGT1A7 but not by UGT1A4 | Oryctolagus cuniculus | UDP + ? | - |
? | |
additional information | tertiary amines give quaternary ammonium glucuronides when conjugated by UGT1A7 but not by UGT1A4 | Oryctolagus cuniculus | ? | - |
? |