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Literature summary for 2.4.1.17 extracted from

  • Irshaid, Y.M.; Tephly, T.R.
    Isolation and purification of two human liver UDP-glucuronosyltransferases (1987), Mol. Pharmacol., 31, 27-34.
    View publication on PubMed
Search for more literature for 2.4.1.17

Activating Compound

Activating Compound Comment Organism Structure
phosphatidylcholine required by purified preparations for optimal activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 x * 53000, isozyme 1 Homo sapiens
54000
-
 x * 54000, isozyme 2 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
two isozymes purified with chromatofocusing and UDP-hexanolamine Sepharose 4B affinity chromatography Homo sapiens

Renatured (Commentary)

Renatured (Comment) Organism
phospholipid required for reconstitution Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-aminobiphenyl + UDPglucuronate catalyzed by isozyme 1 but not by isozyme 2 Homo sapiens UDP + ?
-
 ?
4-methylumbelliferone + UDP-glucuronate
-
 Homo sapiens UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide
-
 ?
4-nitrophenol + UDP-glucuronate
-
 Homo sapiens 4-nitrophenyl beta-D-glucuronide + UDP
-
 ?
alpha-naphthylamine + UDPglucuronate
-
 Homo sapiens UDP + ?
-
 ?
beta-estradiol + UDPglucuronate inactive Homo sapiens beta-estradiol-3-glucuronide + UDP
-
 ?
estriol + UDPglucuronate catalyzed by isozyme 1 but not by isozyme 2 Homo sapiens UDP + estriol-16 alpha-glucuronide
-
 ?
estrone + UDPglucuronate inactive Homo sapiens UDP + estrone 3-O-glucuronide
-
 ?
additional information 36 substrates for HGT2B7H and HGT2B7Y. HGT2B7 glucuronidates both hydroxyl and carboxyl functions of bile acids, retinols and hydroxylated fatty acids Homo sapiens ?
-
 ?
additional information no activity with androsterone, 5alpha-androstane-3alpha,17beta-diol Homo sapiens ?
-
 ?
testosterone + UDPglucuronate no activity Homo sapiens UDP + testosterone O-glucuronide
-
 ?

Subunits

Subunits Comment Organism
? x * 54000, isozyme 2 Homo sapiens
? x * 53000, isozyme 1 Homo sapiens
? all values determined by SDS-PAGE Homo sapiens