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Literature summary for 2.4.1.17 extracted from
- Assay and properties of dititonin-activated bilirubin uridine diphosphate glucuronyltransferase from rat liver (1972), Biochem. J., 129, 605-618.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Digitonin | activation | Rattus norvegicus |  |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | can partially replace Mg2+ | Rattus norvegicus | |
| Co2+ | can partially replace Mg2+ | Rattus norvegicus | |
| Cu2+ | can partially replace Mg2+ | Rattus norvegicus | |
| Mg2+ | activation, can be partially replaced by Mn2+, Ca2+, Co2+, Cd2+, Fe2+, Pb2+ | Rattus norvegicus | |
| additional information | slight stimulatory effect with Cd2+ and Fe2+ | Rattus norvegicus | |
| Zn2+ | can partially replace Mg2+ | Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar strain | - |
| Rattus norvegicus Wistar | - |
Wistar strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
assay conditions | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| bilirubin + UDPglucuronate | - |
Rattus norvegicus | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
| bilirubin + UDPglucuronate | - |
Rattus norvegicus Wistar | bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
- |
Rattus norvegicus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
bilirubin | Rattus norvegicus |
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