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Literature summary for 2.4.1.17 extracted from
- Substrate specificity and properties of uridine diphosphate glucuronyltransferase purified to apparent homogeneity from phenobarbital-treated rat liver (1978), Biochem. J., 173, 749-757.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Diethylnitrosamine | 10 mM, 2-3fold increase activity towards 2-aminophenol | Rattus norvegicus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 5.4 | - |
UDPglucuronic acid | - |
Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 57000 | - |
x * 57000, SDS-polyacrylamide gel electrophoresis | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Wistar strain | - |
| Rattus norvegicus Wistar | - |
Wistar strain | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Rattus norvegicus |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, 20% w/v glycerol, complete loss of activity | Rattus norvegicus |
| 0°C, half-life 18-20 days | Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-naphthol + UDP-glucuronate | - |
Rattus norvegicus | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
| 1-naphthol + UDP-glucuronate | - |
Rattus norvegicus Wistar | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
| 4-nitrophenol + UDP-glucuronate | - |
Rattus norvegicus | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
| 4-nitrophenol + UDP-glucuronate | - |
Rattus norvegicus Wistar | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
| morphine + UDP-glucuronate | - |
Rattus norvegicus | UDP + morphine 3,6-diglucuronide | - |
? | |
| morphine + UDP-glucuronate | - |
Rattus norvegicus Wistar | UDP + morphine 3,6-diglucuronide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 57000, SDS-polyacrylamide gel electrophoresis | Rattus norvegicus |
| ? | additional values for rat isozymes ranging from 51000 to 59000 | Rattus norvegicus |
| ? | all values determined by SDS-PAGE | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
inactivation in 15 min | Rattus norvegicus |
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Release 2023.1 (January 2023)
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