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Literature summary for 2.4.1.17 extracted from

  • Leakey, J.E.A.
    An improved assay technique for uridine diphosphate glucuronosyltransferase activity towards 5-hydroxytryptamine and some properties of the enzyme (1978), Biochem. J., 175, 1119-1124.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.17

Activating Compound

Activating Compound Comment Organism Structure
Diethylnitrosamine 5-10 fold increased activity towards o-aminophenol Rattus norvegicus
Digitonin
-
 Rattus norvegicus
Digitonin 7fold to 12fold increased activity Mus musculus
UDP-N-acetylglucosamine activation Mus musculus
UDP-N-acetylglucosamine activation Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Mus musculus
-
-
microsome
-
 Rattus norvegicus
-
-
microsome
-
 Felis catus
-
-

Organism

Organism UniProt Comment Textmining
Felis catus
-
-
-
Mus musculus
-
-
-
Rattus norvegicus
-
 Wistar strain
-
Rattus norvegicus
-
 Gunn strain
-
Rattus norvegicus
-
 bilirubin UDP-glucuronosyltransferase not in Gunn strain
-
Rattus norvegicus
-
 distribution in Wistar and Gunn strain
-
Rattus norvegicus Gunn
-
 Gunn strain
-
Rattus norvegicus Gunn
-
 bilirubin UDP-glucuronosyltransferase not in Gunn strain
-
Rattus norvegicus Gunn
-
 distribution in Wistar and Gunn strain
-
Rattus norvegicus Wistar
-
 Wistar strain
-

Source Tissue

Source Tissue Comment Organism Textmining
duodenum
-
 Rattus norvegicus
-
kidney
-
 Mus musculus
-
kidney
-
 Rattus norvegicus
-
liver
-
 Mus musculus
-
liver
-
 Rattus norvegicus
-
liver
-
 Felis catus
-
lung
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
bilirubin + UDPglucuronate Gunn strain liver enzyme inactive Rattus norvegicus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
bilirubin + UDPglucuronate cat liver enzyme active Felis catus bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
bilirubin + UDPglucuronate Gunn strain liver enzyme inactive Rattus norvegicus Gunn bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
bilirubin + UDPglucuronate Gunn strain liver enzyme inactive Rattus norvegicus Wistar bilirubin monoglucuronoside + bilirubin diglucuronoside + UDP
-
 ?
serotonin + UDPglucuronate i.e. 5-hydroxytryptamine, liver enzyme inactive Felis catus tryptamine 5-O-beta-D-glucuronide + UDP
-
 ?
serotonin + UDPglucuronate Gunn strain liver enzyme active Rattus norvegicus tryptamine 5-O-beta-D-glucuronide + UDP
-
 ?
serotonin + UDPglucuronate Gunn strain liver enzyme active Rattus norvegicus Gunn tryptamine 5-O-beta-D-glucuronide + UDP
-
 ?
serotonin + UDPglucuronate Gunn strain liver enzyme active Rattus norvegicus Wistar tryptamine 5-O-beta-D-glucuronide + UDP
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.7
-
-
 Mus musculus