Any feedback?
Literature summary for 2.4.1.17 extracted from
- Separation, purification and characterization of three isoenzymes of UDP-glucuronyltransferase from rat liver microsomes (1983), Arch. Biochem. Biophys., 227, 248-258.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| 3-methylcholanthrene | marked induction of hepatic microsomal UDPGT activity, sevenfold increase in the rate of 4-methylumbelliferone glucuronidation, more than 3fold increase towards 4-nitrophenol and fourfold increase towards 1-naphthol | Rattus norvegicus |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Rattus norvegicus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
3-OH androgenic UDP-glucuronyltransferase, chromatofocusing and affinity chromatography | Rattus norvegicus |
| 56000 | - |
3-methylcholanthrene-inducible 4-nitrophenol UDP-glucuronyltransferase, chromatofocusing and affinity chromatography | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
Sprague-Dawley rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| chromatofocusing and affinity chromatography on UDP-hexanolamine sepharose, three isoenzymes | Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1-naphthol + UDP-glucuronate | - |
Rattus norvegicus | naphth-1-yl-beta-D-glucuronide + UDP | - |
? | |
| 4-methylumbelliferone + UDP-glucuronate | - |
Rattus norvegicus | UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide | - |
? | |
| 4-nitrophenol + UDP-glucuronate | 3-methylcholanthrene-inducible 4-nitrophenol UDP-glucuronyltransferase and 17-OH steroid UDP-glucuronyltransferase isoenzymes | Rattus norvegicus | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
| androsterone + UDPglucuronate | - |
Rattus norvegicus | UDP + androsterone O-glucuronide | - |
? | |
| beta-estradiol + UDPglucuronate | - |
Rattus norvegicus | beta-estradiol-3-glucuronide + UDP | - |
? | |
| etiocholanone + UDPglucuronate | 3-OH androgenic UDP-glucuronyltransferase isoenzyme | Rattus norvegicus | UDP + etiocholanone O-glucuronide | - |
? | |
| testosterone + UDPglucuronate | isozyme 17-OH steroid UDPGT | Rattus norvegicus | UDP + testosterone O-glucuronide | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | 4-nitrophenol UDP-glucuronyltransferase | Rattus norvegicus |
| ? | all values determined by SDS-PAGE | Rattus norvegicus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| -60 | - |
as pellets with a 1.15% KCl overlay, no apparent loss of activity for three months | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
