Protein Variants | Comment | Organism |
---|---|---|
additional information | adults treated with dsRNA for TcCHS-B exhibit little or no chitin in their PM and die about 2 weeks after injection, none of the TcCHS-B-treated females oviposite, which is probably a secondary effect caused by starvation, overview | Tribolium castaneum |
additional information | when dsRNA for gene TcCHS-A is injected into male or female pharate adults, all insects die 5-7 d after the adult molt, and the females fail to oviposit prior to death, when dsTcCHS-A is injected into young adults 1-2 d post-eclosion, a similar lethal phenotype is obtained after 5 d and no oviposition occurs, when dsTcCHS-A injections are delayed until after adult maturation 7-10 d post-eclosion, the treated females do oviposit and the resulting embryos appear to develop normally, however, the chitin content of the eggs is dramatically reduced, the embryos became twisted and enlarged, and the eggs do not hatch, overview | Tribolium castaneum |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
membrane | - |
Tribolium castaneum | 16020 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Tribolium castaneum | chitin, synthesized by chitin synthase, is essential for the structural integrity of the exoskeletal cuticle and midgut peritrophic membrane of insects | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Tribolium castaneum | Q6WD22 | class-B CHS; red flour beetle, gene TcCHS-B | - |
Tribolium castaneum | Q6WD23 | class-A CHS; red flour beetle, gene TcCHS-A | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | gene TcCHS-A expression during embryonic and adult development, overview | Tribolium castaneum | - |
additional information | gene TcCHS-B expression during embryonic and adult development, overview | Tribolium castaneum | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | chitin, synthesized by chitin synthase, is essential for the structural integrity of the exoskeletal cuticle and midgut peritrophic membrane of insects | Tribolium castaneum | ? | - |
? | |
additional information | CHS catalyzes the synthesis of chitin, the beta-1,4-linked polymer of N-acetylglucosamine | Tribolium castaneum | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
CHS | - |
Tribolium castaneum |
class-A CHS | - |
Tribolium castaneum |
class-B CHS | - |
Tribolium castaneum |