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Literature summary for 2.4.1.147 extracted from

  • Wang, H.; Kim, J.J.; Denou, E.; Gallagher, A.; Thornton, D.J.; Shajib, M.S.; Xia, L.; Schertzer, J.D.; Grencis, R.K.; Philpott, D.J.; Khan, W.I.
    New role of Nod proteins in regulation of intestinal goblet cell response in the context of innate host defense in an enteric parasite infection (2015), Infect. Immun., 84, 275-285.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
gene B3gnt6 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information C3GnT-deficient mice on a C57BL/6 background Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus Q3USF0 gene B3gnt6
-
Mus musculus C57BL/6 Q3USF0 gene B3gnt6
-

Source Tissue

Source Tissue Comment Organism Textmining
goblet cell
-
 Mus musculus
-
intestine
-
 Mus musculus
-
LS174T cell
-
 Mus musculus
-

Synonyms

Synonyms Comment Organism
C3GnT
-
 Mus musculus
core 3 beta1,3-N-acetylglucosaminyltransferase
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus stimulation of mucin-secreting LS174T cells with Nod1 and Nod2 agonists upregulates core 3 beta1,3-N-acetylglucosaminyltransferase and mucin 2 up

General Information

General Information Comment Organism
malfunction disruption of the C3GnT gene reduces levels of colon-specific Muc2 protein. Nod agonists fail to enhance goblet cell numbers and Muc2 production in C3GnT deficient mice Mus musculus
physiological function the enzyme is an important enzyme in mucin and core 3-derived O-glycans synthesis. Role of Nod proteins in regulation of intestinal goblet cell response in naive mice and mice infected with the enteric parasite Trichuris muris, overview. Nod proteins are important in postive enzyme regulation, treatment with Nod agonists upregulates C3GnT expression both in vivo and in vitro, overview Mus musculus