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Literature summary for 2.4.1.147 extracted from

  • Iwai, T.; Kudo, T.; Kawamoto, R.; Kubota, T.; Togayachi, A.; Hiruma, T.; Okada, T.; Kawamoto, T.; Morozumi, K.; Narimatsu, H.
    Core 3 synthase is down-regulated in colon carcinoma and profoundly suppresses the metastatic potential of carcinoma cells (2005), Proc. Natl. Acad. Sci. USA, 102, 4572-4577.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine the enzyme would be a useful marker for distinguishing between benign adenomas and premalignant lesions Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus in normal stomach and colon the enzyme is strongly expressed in the Golgi region of the epithelium Homo sapiens 5794
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens expression of the enzyme is closely regulated during differentiation and dedifferentiation. Rge expression of the enzyme dramatically decreased in cancerous tissues, and the changes to the core structures of O-glycans give rise to phenotypic changes of cancer cells, such as mobility and metastatic activity ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
Caco-2 cell expression of the enzyme is markedly down-regulated in gastric and colorectal carcinomas Homo sapiens
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colon in normal stomach and colon the enzyme is strongly expressed in the Golgi region of the epithelium Homo sapiens
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stomach in normal stomach and colon the enzyme is strongly expressed in the Golgi region of the epithelium Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information expression of the enzyme is closely regulated during differentiation and dedifferentiation. Rge expression of the enzyme dramatically decreased in cancerous tissues, and the changes to the core structures of O-glycans give rise to phenotypic changes of cancer cells, such as mobility and metastatic activity Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
beta3Gn-T6
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Homo sapiens
core 3 synthase
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Homo sapiens