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Literature summary for 2.4.1.144 extracted from

  • Hanashima, S.; Korekane, H.; Taniguchi, N.; Yamaguchi, Y.
    Synthesis of N-glycan units for assessment of substrate structural requirements of N-acetylglucosaminyltransferase III (2014), Bioorg. Med. Chem. Lett., 24, 4533-4537.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
methyl 3,6-di-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl-2-O-alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside
-
Homo sapiens
methyl 3,6-di-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl-2-O-alpha-D-mannopyranosyl)-alpha-D-mannopyranoside
-
Homo sapiens
methyl 3,6-di-O-(alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside
-
Homo sapiens
methyl 3,6-di-O-(alpha-D-mannopyranosyl)-alpha-D-mannopyranoside
-
Homo sapiens
additional information systematic synthesis of four N-glycan units, the branching parts of the bisected and non-bisected N-glycans, from a common core trimannose, giving bisected tetra- and hexasaccharides as well as non-bisected tri- and pentasaccharides, and evaluation as enzyme inhibitors, overview. The competitive GnT-III inhibition assay using the synthetic substrates reveals a vital role for the Manbeta(1-4)GlcNAc moiety, GlcNAc at the alpha1,3-branch is also involved in the interaction. Competitive inhibition, overview Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens N-acetylglucosaminyltransferase III is a glycosyltransferase which produces bisected N-glycans by transferring GlcNAc to the 4-position of core mannose ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q09327
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information N-acetylglucosaminyltransferase III is a glycosyltransferase which produces bisected N-glycans by transferring GlcNAc to the 4-position of core mannose Homo sapiens ?
-
?
UDP-N-acetyl-D-glucosamine + GnGnbi-PA the bi-branched N-glycan carrying a pyridylamino (PA) group at the reducing terminus (GnGnbi-PA) serves as a typical acceptor substrate and UDP-GlcNAc as a donor substrate Homo sapiens UDP + 4-(N-acetyl-beta-D-glucosaminyl)-GnGnbi-PA
-
?

Synonyms

Synonyms Comment Organism
GnT-III
-
Homo sapiens
N-acetylglucosaminyltransferase III
-
Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.2
-
methyl 3,6-di-O-(alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside pH and temperature not specified in the publication, versus GnGnbi-PA Homo sapiens
1.4
-
methyl 3,6-di-O-(alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside pH and temperature not specified in the publication, versus UDP-N-acetyl-D-glucosamine Homo sapiens
1.5
-
methyl 3,6-di-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl-2-O-alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside pH and temperature not specified in the publication, versus UDP-N-acetyl-D-glucosamine Homo sapiens
14
-
methyl 3,6-di-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl-2-O-alpha-D-mannopyranosyl)-4-O-(2-deoxy-2-acetamide-beta-D-glucopyranosyl)-alpha-D-mannopyranoside pH and temperature not specified in the publication, versus GnGnbi-PA Homo sapiens

General Information

General Information Comment Organism
physiological function N-acetylglucosaminyltransferase III is a glycosyltransferase which produces bisected N-glycans by transferring GlcNAc to the 4-position of core mannose. Bisected N-glycans are involved in physiological and pathological processes through the functional regulation of their carrier proteins Homo sapiens