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Literature summary for 2.4.1.101 extracted from

  • Abdel Rahman, A.; Ryczko, M.; Nakano, M.; Pawling, J.; Rodrigues, T.; Johswich, A.; Taniguchi, N.; Dennis, J.
    Golgi N-glycan branching N-acetylglucosaminyltransferases I, V and VI promote nutrient uptake and metabolism (2015), Glycobiology, 25, 225-240.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.101

Cloned(Commentary)

Cloned (Comment) Organism
recombinant tet-inducible expression of Flag-tagged GlcNAcT-I in HeLa and HEK293 cells Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information GlcNAc and tet-induced Mgat1 increases the levels of many metabolites in HeLa cells, and HEK293 cells, tet-induced Mgat1 changes in the N-glycan distributions, , N-glycans profiles of transgenic HeLa and HEK-293 cells, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
 Homo sapiens 5794
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
53000
-
 x * 53000, SDS-PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R Homo sapiens
-
 UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P26572
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R
-
 Homo sapiens UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
 ?

Subunits

Subunits Comment Organism
? x * 53000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
GlcNAcT-I
-
 Homo sapiens
Golgi N-glycan branching N-acetylglucosaminyltransferase I
-
 Homo sapiens
MGAT1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in the N-glycan-branching pathway, overview. Regulation of cellular metabolite levels by Mgat1, overview Homo sapiens