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Literature summary for 2.4.1.101 extracted from

  • Sourrouille, C.; Marquet-Blouin, E.; DAoust, M.A.; Kiefer-Meyer, M.C.; Seveno, M.; Pagny-Salehabadi, S.; Bardor, M.; Durambur, G.; Lerouge, P.; Vezina, L.; Gomord, V.
    Down-regulated expression of plant-specific glycoepitopes in alfalfa (2008), Plant Biotechnol. J., 6, 702-721.
    View publication on PubMed

Application

Application Comment Organism
biotechnology the fusion of the human beta 1,4-galacosyltransferase with the targeting domain of Nicotiana N-acetylglucosaminyltransferase I does not increase the level of beta 1,4-galactosylation in alfalfa, the expression in alfalfa strongly reduces the biosynthesis of Lewis a glycoepitope responsible for plant N-glycan immunogenicity in mammals Nicotiana tabacum

Cloned(Commentary)

Cloned (Comment) Organism
Agrobacterium-mediated transformation of alfalfa Nicotiana tabacum

Protein Variants

Protein Variants Comment Organism
additional information the fusion of the human beta 1,4-galactosyltransferase with the targeting domain of Nicotiana N-acetylglucosaminyltransferase I does not increase the level of beta 1,4-galactosylation in alfalfa Nicotiana tabacum

Localization

Localization Comment Organism GeneOntology No. Textmining
Golgi apparatus
-
Nicotiana tabacum 5794
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetylglucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R Nicotiana tabacum
-
UDP + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
-
?

Organism

Organism UniProt Comment Textmining
Nicotiana tabacum
-
expressed in alfalfa together with human beta 1,4-galacosyltransferase
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetylglucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R
-
Nicotiana tabacum UDP + 3-(2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)-beta-D-mannosyl-R
-
?

Synonyms

Synonyms Comment Organism
N-acetylglucosaminyltransferase I
-
Nicotiana tabacum