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Literature summary for 2.4.1.101 extracted from

  • Matsunami, K.; Miyagawa, S.; Nakagawa, K.; Otsuka, H.; Hideaki, O.; Shirakura, R.
    Molecular cloning of pigGnT-I and I.2: an application to xenotransplantation (2006), Biochem. Biophys. Res. Commun., 343, 677-683.
    View publication on PubMed

Application

Application Comment Organism
medicine mutant enzyme does not show any activity in an HPLC analysis. In the case of pig cell transfectants with pigGnT-I(320), cell surface carbohydrate structures are significantly altered and its antigenicity to human serum is reduced. pigGnT-I(320) appears to be potentially useful in xenotransplantation by remodeling the carbohydrate structures on pig cells Sus scrofa

Cloned(Commentary)

Cloned (Comment) Organism
-
Sus scrofa

Protein Variants

Protein Variants Comment Organism
C123R mutant enzyme does not show any activity in an HPLC analysis Sus scrofa
G320D mutant enzyme does not show any activity in an HPLC analysis. In the case of pig cell transfectants with pigGnT-I(320), cell surface carbohydrate structures are significantly altered and its antigenicity to human serum is reduced Sus scrofa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R Sus scrofa
-
UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
?

Organism

Organism UniProt Comment Textmining
Sus scrofa
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + 3-(alpha-D-mannosyl)-beta-D-mannosyl-R
-
Sus scrofa UDP + 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R
-
?

Synonyms

Synonyms Comment Organism
pigGnT-I
-
Sus scrofa