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Literature summary for 2.3.3.5 extracted from

  • Claes, W.A.; Puehler, A.; Kalinowski, J.
    Identification of two prpDBC gene clusters in Corynebacterium glutamicum and their involvement in propionate degradation via the 2-methylcitrate cycle (2002), J. Bacteriol., 184, 2728-2739.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
genome sequencing, prpDBC gene cluster, prpC2 gene for 2-methylcitrate synthase, cloned into vector pTrc99a and expressed in Escherichia coli Corynebacterium glutamicum

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
42570
-
prpC1, amino acid sequence calculated from cDNA Corynebacterium glutamicum
42600
-
prpC2, amino acid sequence calculated from cDNA Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
propanoyl-CoA + H2O + oxaloacetate Aspergillus nidulans
-
2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Corynebacterium glutamicum
-
2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Escherichia coli
-
2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Cupriavidus metallidurans
-
2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Salmonella enterica
-
2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Escherichia coli first key enzyme of the methylcitric acid cycle 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Pseudomonas aeruginosa first key enzyme of the methylcitric acid cycle 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Yarrowia lipolytica first key enzyme of the methylcitric acid cycle 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Corynebacterium glutamicum first key enzyme of the methylcitric acid cycle 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Paraburkholderia sacchari first key enzyme of the methylcitric acid cycle 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate Cupriavidus metallidurans first key enzyme of the methylcitric acid cycle 2-methylcitrate + CoA
-
?

Organism

Organism UniProt Comment Textmining
Aspergillus nidulans
-
-
-
Corynebacterium glutamicum
-
ATCC 13032
-
Corynebacterium glutamicum Q8NSH7 ATCC 13032, prp gene cluster
-
Corynebacterium glutamicum Q8NSL1 ATCC 13032, prp gene cluster
-
Cupriavidus metallidurans
-
-
-
Cupriavidus metallidurans Q937N9 formerly Ralstonia eutropha, HF39 prp gene cluster
-
Cupriavidus metallidurans Q937N9 formerly Ralstonia eutropha, prp gene cluster
-
Escherichia coli
-
-
-
Escherichia coli P31660 prp gene cluster
-
Paraburkholderia sacchari
-
-
-
Pseudomonas aeruginosa
-
-
-
Salmonella enterica Q56063 serovar Typhimurium, prp gene cluster
-
Yarrowia lipolytica
-
formerly Candida lipolytica
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
propanoyl-CoA + H2O + oxaloacetate
-
Escherichia coli 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate
-
Aspergillus nidulans 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate
-
Pseudomonas aeruginosa 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate
-
Yarrowia lipolytica 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate
-
Corynebacterium glutamicum 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate
-
Paraburkholderia sacchari 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate
-
Cupriavidus metallidurans 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate
-
Salmonella enterica 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate first key enzyme of the methylcitric acid cycle Escherichia coli 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate first key enzyme of the methylcitric acid cycle Pseudomonas aeruginosa 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate first key enzyme of the methylcitric acid cycle Yarrowia lipolytica 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate first key enzyme of the methylcitric acid cycle Corynebacterium glutamicum 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate first key enzyme of the methylcitric acid cycle Paraburkholderia sacchari 2-methylcitrate + CoA
-
?
propanoyl-CoA + H2O + oxaloacetate first key enzyme of the methylcitric acid cycle Cupriavidus metallidurans 2-methylcitrate + CoA
-
?

Synonyms

Synonyms Comment Organism
PrpC
-
Corynebacterium glutamicum