Cloned (Comment) | Organism |
---|---|
expressed in Hep-G2 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + H2O + oxaloacetate | - |
Mus musculus | citrate + CoA | - |
? | |
acetyl-CoA + H2O + oxaloacetate | - |
Homo sapiens | citrate + CoA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
citrate synthase | - |
Mus musculus |
citrate synthase | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Mus musculus | the mRNA expression of citrate synthase in liver is reduced by 42% in the staggerer mice (which possess a nonfunctional retinoic acid receptor-related orphan receptor alpha protein) relative to the wild type mice | down |
Homo sapiens | overexpression of retinoic acid receptor-related orphan receptor alpha (5fold), leads to a 94% increase in citrate synthase mRNA levels and enzyme activity in Hep-G2 cells | up |
General Information | Comment | Organism |
---|---|---|
metabolism | citrate synthase is a key enzyme of the citric acid cycle that provides energy for cellular function. Additionally, the enzyme plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis | Mus musculus |
metabolism | citrate synthase is a key enzyme of the citric acid cycle that provides energy for cellular function. Additionally, the enzyme plays a critical role in providing citrate derived acetyl-CoA for lipogenesis and cholesterologenesis | Homo sapiens |
physiological function | the citrate synthase gene is a direct retinoic acid receptor-related orphan receptor alpha target and one mechanism by which retinoic acid receptor-related orphan receptor alpha regulates lipid metabolism is via regulation of citrate synthase expression | Mus musculus |
physiological function | the citrate synthase gene is a direct retinoic acid receptor-related orphan receptor alpha target and one mechanism by which retinoic acid receptor-related orphan receptor alpha regulates lipid metabolism is via regulation of citrate synthase expression | Homo sapiens |