Activating Compound | Comment | Organism | Structure |
---|---|---|---|
EDTA | the enzymatic activity increases by about 55% in the presence of 1 mM EDTA | Ixodes scapularis |
Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) CodonPlus-RIL cells | Ixodes scapularis |
Crystallization (Comment) | Organism |
---|---|
sitting drop vapor diffusion method, using 10% (w/v) PEG 8000, 8% (v/v) ethylene glycol, 0.1 M HEPES pH 7.5 | Ixodes scapularis |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,10-phenanthroline | - |
Ixodes scapularis | |
1-Benzylimidazole | - |
Ixodes scapularis | |
dipicolinic acid | - |
Ixodes scapularis | |
Nomega-acetylhistamine | - |
Ixodes scapularis | |
PBD150 | - |
Ixodes scapularis |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0218 | - |
L-glutaminyl 2-naphthylamide | at pH 8.0 and 25°C | Ixodes scapularis |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
additional information | the enzyme is metal-independent | Ixodes scapularis | |
Zn2+ | 0.5 mol of zinc per mole of enzyme | Ixodes scapularis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutaminyl-peptide | Ixodes scapularis | - |
5-oxoprolyl-peptide + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Ixodes scapularis | B7QK46 | - |
- |
Purification (Comment) | Organism |
---|---|
Ni-NTA column chromatography and Sephacryl S-100 gel filtration | Ixodes scapularis |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-glutaminyl 2-naphthylamide | - |
Ixodes scapularis | L-glutamine + 2-naphthylamine | - |
? | |
L-glutaminyl-peptide | - |
Ixodes scapularis | 5-oxoprolyl-peptide + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutaminyl cyclase | - |
Ixodes scapularis |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
53 | - |
melting temperature | Ixodes scapularis |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
8.8 | - |
L-glutaminyl 2-naphthylamide | at pH 8.0 and 25°C | Ixodes scapularis |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000342 | - |
PBD150 | at pH 8.0 and 25°C | Ixodes scapularis | |
0.00345 | - |
1,10-phenanthroline | at pH 8.0 and 25°C | Ixodes scapularis | |
0.0102 | - |
1-Benzylimidazole | at pH 8.0 and 25°C | Ixodes scapularis | |
0.0142 | - |
Nomega-acetylhistamine | at pH 8.0 and 25°C | Ixodes scapularis | |
0.0368 | - |
dipicolinic acid | at pH 8.0 and 25°C | Ixodes scapularis |