Cloned (Comment) | Organism |
---|---|
expressed in Pichia pastoris | Mus musculus |
expressed in Pichia pastoris | Homo sapiens |
expressed in Pichia pastoris | Solanum tuberosum |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
EFRH-NH2 | competitive inhibitor with L-glutaminyl-7-amido-4-methylcumarin as substrate | Homo sapiens | |
EFRH-NH2 | competitive inhibitor with L-glutaminyl-7-amido-4-methylcumarin as substrate | Mus musculus | |
EFRHHDSGYE-NH2 | competitive inhibitor with L-glutaminyl-7-amido-4-methylcumarin as substrate | Homo sapiens | |
EFRHHDSGYE-NH2 | competitive inhibitor with L-glutaminyl-7-amido-4-methylcumarin as substrate | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.6 | - |
EFRHHDSGYE-NH2 | - |
Homo sapiens | |
6 | - |
EFRH-NH2 | at pH 6.5, 10times higher compared to KM-value of Gln substrate | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Zn2+ | - |
Mus musculus | |
Zn2+ | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Carica papaya | - |
- |
- |
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Solanum tuberosum | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
- |
Homo sapiens |
- |
Solanum tuberosum |
- |
Carica papaya |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
EFRH-NH2 | - |
Mus musculus | pEFRH-NH2 + H2O | - |
? | |
EFRH-NH2 | - |
Homo sapiens | pEFRH-NH2 + H2O | - |
? | |
EFRH-NH2 | - |
Solanum tuberosum | pEFRH-NH2 + H2O | - |
? | |
EFRH-NH2 | - |
Carica papaya | pEFRH-NH2 + H2O | - |
? | |
EFRHHDSGYE-NH2 | - |
Mus musculus | pEFRHHDSGYE-NH2 + H2O | - |
? | |
EFRHHDSGYE-NH2 | - |
Homo sapiens | pEFRHHDSGYE-NH2 + H2O | - |
? | |
EFRHHDSGYE-NH2 | - |
Solanum tuberosum | pEFRHHDSGYE-NH2 + H2O | - |
? | |
EFRHHDSGYE-NH2 | - |
Carica papaya | pEFRHHDSGYE-NH2 + H2O | - |
? | |
L-glutaminyl-7-amido-4-methylcoumarin | - |
Homo sapiens | pGlu-7-amido-4-methylcoumarin + NH3 | - |
? | |
QFRH-NH2 | - |
Mus musculus | pEFRH-NH2 + NH3 | - |
? | |
QFRH-NH2 | - |
Homo sapiens | pEFRH-NH2 + NH3 | - |
? | |
QFRH-NH2 | - |
Solanum tuberosum | pEFRH-NH2 + NH3 | - |
? | |
QFRH-NH2 | - |
Carica papaya | pEFRH-NH2 + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutaminyl cyclase | - |
Mus musculus |
glutaminyl cyclase | - |
Homo sapiens |
glutaminyl cyclase | - |
Solanum tuberosum |
glutaminyl cyclase | - |
Carica papaya |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00022 | - |
EFRH-NH2 | at pH 6.5, 150000fold lower compared to Gln substrate | Homo sapiens | |
0.00042 | - |
EFRHHDSGYE-NH2 | - |
Homo sapiens | |
30 | - |
QFRH-NH2 | at pH 6.5 | Homo sapiens | |
40 | - |
QFRH-NH2 | at pH 6.5 | Mus musculus | |
42 | - |
QFRH-NH2 | at pH 6.5 | Carica papaya | |
56 | - |
QFRH-NH2 | at pH 6.5 | Solanum tuberosum |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.8 | - |
EFRH-NH2 as substrate | Homo sapiens |
7.5 | 7.8 | Gln-peptide as substrate | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
3.25 | - |
EFRH-NH2 | at pH 8.0 | Homo sapiens | |
4.69 | - |
EFRHHDSGYE-NH2 | at pH 8.0 | Homo sapiens | |
6.1 | - |
EFRHHDSGYE-NH2 | at pH 8.0 | Mus musculus | |
8.32 | - |
EFRHHDSGYE-NH2 | at pH 6.0 | Homo sapiens | |
8.33 | - |
EFRH-NH2 | at pH 8.0 | Mus musculus | |
10.4 | - |
EFRHHDSGYE-NH2 | at pH 6.0 | Mus musculus | |
24.64 | - |
EFRH-NH2 | at pH 6.0 | Homo sapiens | |
35.75 | - |
EFRH-NH2 | at pH 6.0 | Mus musculus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000019 | - |
EFRH-NH2 | at pH 6.5 | Mus musculus | |
0.000037 | - |
EFRH-NH2 | at pH 6.5 | Homo sapiens | |
0.000073 | - |
EFRHHDSGYE-NH2 | at low substrate concentrations | Homo sapiens | |
0.00009 | - |
EFRHHDSGYE-NH2 | - |
Homo sapiens | |
0.00017 | - |
EFRH-NH2 | at pH 6.5 | Solanum tuberosum | |
0.00074 | - |
EFRH-NH2 | at pH 6.5 | Carica papaya | |
98.9 | - |
QFRH-NH2 | at pH 6.5 | Solanum tuberosum | |
100 | - |
QFRH-NH2 | at pH 6.5 | Homo sapiens | |
135 | - |
QFRH-NH2 | at pH 6.5 | Mus musculus | |
145 | - |
QFRH-NH2 | at pH 6.5 | Carica papaya |