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Literature summary for 2.3.2.5 extracted from

  • Sykes, P.A.; Watson, S.J.; Temple, J.S.; Bateman, R.C., Jr.
    Evidence for tissue-specific forms of glutaminyl cyclase (1999), FEBS Lett., 455, 159-161.
    View publication on PubMed

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble a 40000 Da enzyme form is exclusively detected in soluble pituitary extract, a 32000 Da enzyme form is detected in soluble fraction of all tissues which show immunoreactivity. The difference in the two immunoreacive proteins lies in the proteolytic cleavage within a hydrophilic region approximately 80 amino acids from the carboxy-terminus Bos taurus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
48500
-
gel filtration Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Bos taurus
-
pituitary gland
-
Bos taurus
-
spleen
-
Bos taurus
-

Storage Stability

Storage Stability Organism
stable for several weeks Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Gln-Ala
-
Bos taurus Glp-Ala + NH3
-
?
Gln-Gln
-
Bos taurus Glp-Gln + NH3
-
?
Gln-Gln-Gln
-
Bos taurus Glp-Gln-Gln + NH3
-
?
Gln-Glu
-
Bos taurus Glp-Glu + NH3
-
?
Gln-Gly
-
Bos taurus Glp-Gly + NH3
-
?
Gln-Gly-Pro
-
Bos taurus Glp-Gly-Pro + NH3
-
?
Gln-NH2
-
Bos taurus Glp-amide + NH3
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.3
-
pituitary enzyme Bos taurus
8.5
-
enzyme from spleen Bos taurus

pH Range

pH Minimum pH Maximum Comment Organism
6.5 8.3 pH 6.5: about 50% of maximal activity, pH 8.3: about 40% of maximal activity, pituitary enzyme Bos taurus
7.5 9.3 pH 7.5: about 55% of maximal activity, pH 9.3: about 45% of maximal activity, enzyme from spleen Bos taurus