Literature summary for 2.3.1.86 extracted from
No PubMed abstract available
Activating Compound
Activating Compound |
Comment |
Organism |
Structure |
cysteine |
activation |
Saccharomyces cerevisiae |
|
glutathione |
activation |
Saccharomyces cerevisiae |
|
General Stability
General Stability |
Organism |
2-mercaptoethanol, inactivation during storage |
Saccharomyces cerevisiae |
Inhibitors
Inhibitors |
Comment |
Organism |
Structure |
iodoacetamide |
no inhibition of acetyl transferase activity; pH-independent between 5.0 and 9.0 |
Saccharomyces cerevisiae |
|
N-ethylmaleimide |
no inhibition of acetyl transferase activity; pH-dependent |
Saccharomyces cerevisiae |
|
KM Value [mM]
KM Value [mM] |
KM Value Maximum [mM] |
Substrate |
Comment |
Organism |
Structure |
additional information |
- |
additional information |
specific activities for acetyl-CoA derivatives |
Saccharomyces cerevisiae |
|
0.067 |
- |
NADPH |
- |
Saccharomyces cerevisiae |
|
Molecular Weight [Da]
Molecular Weight [Da] |
Molecular Weight Maximum [Da] |
Comment |
Organism |
2300000 |
- |
sedimentation equilibrium |
Saccharomyces cerevisiae |
Natural Substrates/ Products (Substrates)
Natural Substrates |
Organism |
Comment (Nat. Sub.) |
Natural Products |
Comment (Nat. Pro.) |
Rev. |
Reac. |
acetyl-CoA + malonyl-CoA + NADH + NADPH |
Saccharomyces cerevisiae |
multifunctional enzyme involved in yeast fat metabolism |
? |
- |
? |
|
Organism
Organism |
UniProt |
Comment |
Textmining |
Saccharomyces cerevisiae |
- |
baker's yeast |
- |
Purification (Commentary)
Purification (Comment) |
Organism |
- |
Saccharomyces cerevisiae |
Reaction
Reaction |
Comment |
Organism |
Reaction ID |
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoyl-CoA + 7 CoA + 7 CO2 + 14 NADP+ + 7 H2O |
reaction mechanism |
Saccharomyces cerevisiae |
|
Specific Activity [micromol/min/mg]
Specific Activity Minimum [µmol/min/mg] |
Specific Activity Maximum [µmol/min/mg] |
Comment |
Organism |
1.5 |
2.5 |
- |
Saccharomyces cerevisiae |
Storage Stability
Storage Stability |
Organism |
-15°C, stable in 90% ammonium sulfate solution containing 0.1 M potassium phosphate, pH 6.5, and 1 mM DTT |
Saccharomyces cerevisiae |
4°C, precipitate in 50% ammonium sulfate solution, several days |
Saccharomyces cerevisiae |
Substrates and Products (Substrate)
Substrates |
Comment Substrates |
Organism |
Products |
Comment (Products) |
Rev. |
Reac. |
acetyl-CoA + 7 malonyl-CoA + 7 NADH + 7 NADPH + 14 H+ |
S-acetylpantetheine and S-malonylpantetheine and saturated acetyl-CoA derivatives can replace acetyl-CoA and malonyl-CoA |
Saccharomyces cerevisiae |
palmitoyl-CoA + 7 CoA + 7 CO2 + 7 NAD+ + 7 NADP+ + 7 H2O |
palmitoyl-CoA and steraoyl-CoA are main products, myristoyl-CoA is produced in small amounts |
? |
|
acetyl-CoA + malonyl-CoA + NADH + NADPH |
multifunctional enzyme involved in yeast fat metabolism |
Saccharomyces cerevisiae |
? |
- |
? |
|
Temperature Optimum [°C]
Temperature Optimum [°C] |
Temperature Optimum Maximum [°C] |
Comment |
Organism |
37 |
- |
assay at |
Saccharomyces cerevisiae |
pH Optimum
pH Optimum Minimum |
pH Optimum Maximum |
Comment |
Organism |
6.5 |
7 |
- |
Saccharomyces cerevisiae |
Cofactor
Cofactor |
Comment |
Organism |
Structure |
FMN |
4 mol FMN per mol of enzyme complex |
Saccharomyces cerevisiae |
|
NADH |
requirement, 25% as efficient as NADPH |
Saccharomyces cerevisiae |
|
NADPH |
requirement |
Saccharomyces cerevisiae |
|