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Literature summary for 2.3.1.85 extracted from

  • Zeng, X.F.; Li, W.W.; Fan, H.J.; Wang, X.Y.; Ji, P.; Wang, Z.R.; Ma, S.; Li, L.L.; Ma, X.F.; Yang, S.Y.
    Discovery of novel fatty acid synthase (FAS) inhibitors based on the structure of ketoaceyl synthase (KS) domain (2011), Bioorg. Med. Chem. Lett., 21, 4742-4744.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
pharmacophore modeling based on crystal structure of 3-oxoacyl-[acyl-carrier-protein] synthase domain, PDB entry 3HHD Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
2-[(Z)-[2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]pyridine good inhibition activity against two enzyme overexpressing cancer cell lines. IC50 value for MDA-MB-468 cell 0.0083 mM, for SW-480 cell 0.0015 mM Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P49327
-
-

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0127
-
pH not specified in the publication, temperature not specified in the publication Homo sapiens 2-[(Z)-[2-[4-(3-nitrophenyl)-1,3-thiazol-2-yl]hydrazinylidene]methyl]pyridine