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Literature summary for 2.3.1.85 extracted from

  • Nguyen, L.N.; Trofa, D.; Nosanchuk, J.D.
    Fatty acid synthase impacts the pathobiology of Candida parapsilosis in vitro and during mammalian infection (2009), PLoS ONE, 4, e8421.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
cerulenin specific inhibitor Candida parapsilosis

Organism

Organism UniProt Comment Textmining
Candida parapsilosis
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-
-

Synonyms

Synonyms Comment Organism
fatty acid synthase
-
Candida parapsilosis

Expression

Organism Comment Expression
Candida parapsilosis oleic acid and Tween 80 downregulate the expression of the fatty acid synthase while myristic acid, stearic acid, and Tween 40 do not down
Candida parapsilosis expression of Fas1 and Fas2 is significantly elevated by the presence of glucose up

General Information

General Information Comment Organism
malfunction Fas2 KO strains are unable to form normal biofilms and are more efficiently killed by murine-like macrophages, J774.16, than the wild type, heterozygous and reconstituted strains, Fas2 KO strains are hypersensitive to human serum, and inhibition of Fas2 in wild type Candida parapsilosis by cerulenin significantly decreases fungal growth in human serum Candida parapsilosis
physiological function the Fas2 gene is essential for fungal growth in fatty acid-free medium, but dispensable in medium with fatty acids Candida parapsilosis