Inhibitors | Comment | Organism | Structure |
---|---|---|---|
cerulenin | specific inhibitor | Candida parapsilosis |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida parapsilosis | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
fatty acid synthase | - |
Candida parapsilosis |
Organism | Comment | Expression |
---|---|---|
Candida parapsilosis | oleic acid and Tween 80 downregulate the expression of the fatty acid synthase while myristic acid, stearic acid, and Tween 40 do not | down |
Candida parapsilosis | expression of Fas1 and Fas2 is significantly elevated by the presence of glucose | up |
General Information | Comment | Organism |
---|---|---|
malfunction | Fas2 KO strains are unable to form normal biofilms and are more efficiently killed by murine-like macrophages, J774.16, than the wild type, heterozygous and reconstituted strains, Fas2 KO strains are hypersensitive to human serum, and inhibition of Fas2 in wild type Candida parapsilosis by cerulenin significantly decreases fungal growth in human serum | Candida parapsilosis |
physiological function | the Fas2 gene is essential for fungal growth in fatty acid-free medium, but dispensable in medium with fatty acids | Candida parapsilosis |