Literature summary for 2.3.1.85 extracted from

Na, M.; Jang, J.; Min, B.S.; Lee, S.J.; Lee, M.S.; Kim, B.Y.; Oh, W.K.; Ahn, J.S.
Fatty acid synthase inhibitory activity of acylphloroglucinols isolated from Dryopteris crassirhizoma (2006), Bioorg. Med. Chem. Lett., 16, 4738-4742.

Search for more literature for 2.3.1.85

Application

Application	Comment	Organism
medicine	the enzyme is a potential therapeutic target to treat cancer and obesity. Acylphloroglucinol derivatives could be considered to be a promising class of FAS inhibitors	Gallus gallus

Inhibitors

Inhibitors	Comment	Organism	Structure
1,1'-[methanediylbis(2,4,6-trihydroxy-5-methylbenzene-3,1-diyl)]dibutan-1-one	IC50: 0.0254 mM	Gallus gallus
1-(2,6-dihydroxy-4-methoxy-3-methylphenyl)butan-1-one	IC50: 0.0491 mM	Gallus gallus
2,2'-methanediylbis(3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one)	IC50: 0.0602 mM	Gallus gallus
2-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one	IC50: 0.0231 mM	Gallus gallus
2-acetyl-6-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one	IC50: 0.0287 mM	Gallus gallus
2-acetyl-6-(3-butanoyl-2,4,6-trihydroxybenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one	IC50: 0.0297 mM	Gallus gallus
2-acetyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one	IC50: 0.0717 mM	Gallus gallus
2-acetyl-6-{3-butanoyl-5-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-2,4,6-trihydroxybenzyl}-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one	IC50: 0.031 mM	Gallus gallus
2-butanoyl-6-(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one	IC50: 0.0326 mM	Gallus gallus
2-butanoyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one	IC50: 0.0561 mM	Gallus gallus
cerulenin	IC50: 0.013 mM	Gallus gallus
luteolin	IC50: 0.0625 mM	Gallus gallus

Organism

Organism	UniProt	Comment	Textmining
Gallus gallus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
liver	-	Gallus gallus	-

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.013	-	IC50: 0.013 mM	Gallus gallus	3-chloro-4-hydroxybenzoyl-[aryl-carrier protein]
0.0231	-	IC50: 0.0231 mM	Gallus gallus	2-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one
0.0254	-	IC50: 0.0254 mM	Gallus gallus	1,1'-[methanediylbis(2,4,6-trihydroxy-5-methylbenzene-3,1-diyl)]dibutan-1-one
0.0287	-	IC50: 0.0287 mM	Gallus gallus	2-acetyl-6-(3-butanoyl-2,4,6-trihydroxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
0.0297	-	IC50: 0.0297 mM	Gallus gallus	2-acetyl-6-(3-butanoyl-2,4,6-trihydroxybenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
0.031	-	IC50: 0.031 mM	Gallus gallus	2-acetyl-6-{3-butanoyl-5-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-2,4,6-trihydroxybenzyl}-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
0.0326	-	IC50: 0.0326 mM	Gallus gallus	2-butanoyl-6-(3-butanoyl-2,6-dihydroxy-4-methoxy-5-methylbenzyl)-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
0.0491	-	IC50: 0.0491 mM	Gallus gallus	1-(2,6-dihydroxy-4-methoxy-3-methylphenyl)butan-1-one
0.0561	-	IC50: 0.0561 mM	Gallus gallus	2-butanoyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one
0.0602	-	IC50: 0.0602 mM	Gallus gallus	2,2'-methanediylbis(3,5-dihydroxy-4,4-dimethyl-6-propanoylcyclohexa-2,5-dien-1-one)
0.0625	-	IC50: 0.0625 mM	Gallus gallus	3-((1H-imidazo)-4-yl)-2-oxopropanoate
0.0717	-	IC50: 0.0717 mM	Gallus gallus	2-acetyl-6-[(2,4-dihydroxy-3,3-dimethyl-6-oxo-5-propanoylcyclohexa-1,4-dien-1-yl)methyl]-3,5-dihydroxy-4,4-dimethylcyclohexa-2,5-dien-1-one

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)