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Literature summary for 2.3.1.85 extracted from

  • Wakil, S.J.; Stoops, J.K.; Joshi, V.C.
    Fatty acid synthesis and its regulation (1983), Annu. Rev. Biochem., 52, 537-579.
    View publication on PubMed
Search for more literature for 2.3.1.85

Cloned(Commentary)

Cloned (Comment) Organism
gene sequences Anser sp.

General Stability

General Stability Organism
dissociation of native enzyme leads to loss of activity Gallus gallus
dissociation of native enzyme leads to loss of activity Mus musculus
dissociation of native enzyme leads to loss of activity Homo sapiens
dissociation of native enzyme leads to loss of activity Rattus norvegicus
dissociation of native enzyme leads to loss of activity Bos taurus
dissociation of native enzyme leads to loss of activity Oryctolagus cuniculus
dissociation of native enzyme leads to loss of activity Canis lupus familiaris
dissociation of native enzyme leads to loss of activity Anser sp.
dissociation of native enzyme leads to loss of activity Columba sp.

Inhibitors

Inhibitors Comment Organism Structure
1,3-Dibromo-2-propanone
-
 Anser sp.
1,3-Dibromo-2-propanone
-
 Bos taurus
1,3-Dibromo-2-propanone
-
 Canis lupus familiaris
1,3-Dibromo-2-propanone
-
 Columba sp.
1,3-Dibromo-2-propanone
-
 Gallus gallus
1,3-Dibromo-2-propanone
-
 Homo sapiens
1,3-Dibromo-2-propanone
-
 Mus musculus
1,3-Dibromo-2-propanone
-
 Oryctolagus cuniculus
1,3-Dibromo-2-propanone
-
 Rattus norvegicus
2,3-Butanedione
-
 Anser sp.
diisopropylfluorophosphate
-
 Anser sp.
diisopropylfluorophosphate
-
 Bos taurus
diisopropylfluorophosphate
-
 Canis lupus familiaris
diisopropylfluorophosphate
-
 Columba sp.
diisopropylfluorophosphate
-
 Gallus gallus
diisopropylfluorophosphate
-
 Homo sapiens
diisopropylfluorophosphate
-
 Mus musculus
diisopropylfluorophosphate
-
 Oryctolagus cuniculus
diisopropylfluorophosphate
-
 Rattus norvegicus
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Anser sp.
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Bos taurus
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Canis lupus familiaris
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Columba sp.
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Gallus gallus
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Homo sapiens
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Mus musculus
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Oryctolagus cuniculus
iodoacetamide beta-ketoacyl synthetase activity, acetyl-CoA but not malonyl-CoA protects Rattus norvegicus
Phenylglyoxal
-
 Anser sp.
PMSF
-
 Anser sp.
PMSF
-
 Bos taurus
PMSF
-
 Canis lupus familiaris
PMSF
-
 Columba sp.
PMSF
-
 Gallus gallus
PMSF
-
 Homo sapiens
PMSF
-
 Mus musculus
PMSF
-
 Oryctolagus cuniculus
PMSF
-
 Rattus norvegicus
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Anser sp.
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Bos taurus
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Canis lupus familiaris
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Columba sp.
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Gallus gallus
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Homo sapiens
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Mus musculus
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Oryctolagus cuniculus
pyridoxal 5'-phosphate enoyl reductase activity, NADPH protects Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Gallus gallus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Mus musculus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Homo sapiens multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Rattus norvegicus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Bos taurus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Oryctolagus cuniculus multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Canis lupus familiaris multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Anser sp. multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ Columba sp. multifunctional enzyme, involved in animal fat synthesis palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Anser sp.
-
 goose
-
Bos taurus
-
-
-
Canis lupus familiaris
-
-
-
Columba sp.
-
 pigeon
-
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Mus musculus
-
-
-
Oryctolagus cuniculus
-
-
-
Rattus norvegicus
-
-
-

Reaction

Reaction Comment Organism Reaction ID
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Gallus gallus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Mus musculus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Homo sapiens
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Rattus norvegicus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Bos taurus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Oryctolagus cuniculus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Canis lupus familiaris
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Anser sp.
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O reaction mechanism Columba sp.
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Gallus gallus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Mus musculus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Homo sapiens
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Rattus norvegicus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Bos taurus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Oryctolagus cuniculus
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Canis lupus familiaris
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Anser sp.
a
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ = hexadecanoate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O structure and regulation Columba sp.
a

Source Tissue

Source Tissue Comment Organism Textmining
adipose tissue
-
 Mus musculus
-
adipose tissue
-
 Rattus norvegicus
-
liver
-
 Gallus gallus
-
liver
-
 Mus musculus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-
liver
-
 Bos taurus
-
liver
-
 Oryctolagus cuniculus
-
liver
-
 Canis lupus familiaris
-
liver
-
 Anser sp.
-
liver
-
 Columba sp.
-
mammary gland
-
 Rattus norvegicus
-
mammary gland lactating Oryctolagus cuniculus
-
uropygial gland
-
 Anser sp.
-

Storage Stability

Storage Stability Organism
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Gallus gallus
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Mus musculus
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Homo sapiens
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Rattus norvegicus
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Bos taurus
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Oryctolagus cuniculus
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Canis lupus familiaris
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Anser sp.
0°C, inactivation after 12 h, reactivation after 2 h at 25°C in the presence of NADPH, not acetyl-CoA or NADH Columba sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Rattus norvegicus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O lactating mammary gland thioesterase II of fatty acid synthetase: products are medium chain fatty acids from C8 to C12 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Oryctolagus cuniculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O lactating mammary gland thioesterase II of fatty acid synthetase: products are medium chain fatty acids from C8 to C12 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Gallus gallus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Mus musculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Homo sapiens palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Rattus norvegicus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Bos taurus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Oryctolagus cuniculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Canis lupus familiaris palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Anser sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Columba sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O C20 and C22 fatty acids in the absence of thioesterase activity ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+
-
 Anser sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O methylmalonyl-CoA instead of malonyl-CoA yields branched fatty acid, e.g. 2,4,6,8-tetramethyldecanoic acid ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Gallus gallus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Mus musculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Homo sapiens palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Rattus norvegicus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Bos taurus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Oryctolagus cuniculus palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Canis lupus familiaris palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Anser sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?
acetyl-CoA + 7 malonyl-CoA + 14 NADPH + 14 H+ multifunctional enzyme, involved in animal fat synthesis Columba sp. palmitate + 8 CoA + 7 CO2 + 14 NADP+ + 6 H2O
-
 ?

Subunits

Subunits Comment Organism
More
-
 Mus musculus
More
-
 Homo sapiens
More
-
 Bos taurus
More
-
 Canis lupus familiaris
More
-
 Anser sp.
More
-
 Columba sp.
More alpha2-dimer of multifunctional subunits: each subunit contains up to seven active centres required for palmitate synthesis Oryctolagus cuniculus
More alpha2-dimer of multifunctional subunits: each subunit contains up to seven active centres required for palmitate synthesis and an acyl carrier site, arranged in three domains but dimer is the only catalytically active form of fatty acid synthase Rattus norvegicus
More condensing enzyme activity requires both subunits Gallus gallus

Cofactor

Cofactor Comment Organism Structure
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Gallus gallus
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Mus musculus
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Homo sapiens
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Rattus norvegicus
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Bos taurus
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Oryctolagus cuniculus
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Canis lupus familiaris
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Anser sp.
4'-phosphopantetheine requirement, 1 mol associated with 1 mol subunit Columba sp.
additional information no requirement for FMN Gallus gallus
additional information no requirement for FMN Mus musculus
additional information no requirement for FMN Homo sapiens
additional information no requirement for FMN Rattus norvegicus
additional information no requirement for FMN Bos taurus
additional information no requirement for FMN Oryctolagus cuniculus
additional information no requirement for FMN Canis lupus familiaris
additional information no requirement for FMN Anser sp.
additional information no requirement for FMN Columba sp.
NADPH requirement, high specificity Gallus gallus
NADPH requirement, high specificity Mus musculus
NADPH requirement, high specificity Homo sapiens
NADPH requirement, high specificity Rattus norvegicus
NADPH requirement, high specificity Bos taurus
NADPH requirement, high specificity Oryctolagus cuniculus
NADPH requirement, high specificity Canis lupus familiaris
NADPH requirement, high specificity Anser sp.
NADPH requirement, high specificity Columba sp.