Literature summary for 2.3.1.82 extracted from

Li, Y.; Green, K.D.; Johnson, B.R.; Garneau-Tsodikova, S.
Inhibition of aminoglycoside acetyltransferase resistance enzymes by metal salts (2015), Antimicrob. Agents Chemother., 59, 4148-4156.

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Inhibitors

Inhibitors	Comment	Organism	Structure
Au3+	-	Pseudomonas aeruginosa
Cd2+	-	Pseudomonas aeruginosa
Zn2+	-	Pseudomonas aeruginosa
Zn2+	-	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Pseudomonas aeruginosa	Q8RPU6	-	-
Staphylococcus aureus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + amikacin	-	Pseudomonas aeruginosa	CoA + N6'-acetylamikacin	-	?
acetyl-CoA + sisomicin	-	Staphylococcus aureus	CoA + N6'-acetylsisomicin	-	?
acetyl-CoA + sisomicin	-	Pseudomonas aeruginosa	CoA + N6'-acetylsisomicin	-	?
acetyl-CoA + tobramicin	-	Staphylococcus aureus	CoA + N6'-acetyltobramicin	-	?

Synonyms

Synonyms	Comment	Organism
aac(3)-Ib/aac(6')-Ib	-	Pseudomonas aeruginosa
AAC(6')-Ie/APH(2')-Ia	-	Staphylococcus aureus
aminoglycoside (3) acetyltransferase AAC(3)-Ia	-	Pseudomonas aeruginosa
aminoglycoside 3-N-acetyltransferase/aminoglycoside 6'-N-acetyltransferase fusion protein	-	Pseudomonas aeruginosa

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.00041	-	substrate amikacin, pH 6.6, 25°C	Pseudomonas aeruginosa	Cd2+
0.00041	-	substrate amikacin, pH 6.6, 25°C	Pseudomonas aeruginosa	Au3+
0.0052	-	substrate tobramicin, pH 6.6, 25°C	Staphylococcus aureus	Zn2+
0.0078	-	substrate sisomicin, pH 6.6, 25°C	Pseudomonas aeruginosa	Zn2+
0.041	-	substrate sisomicin, pH 6.6, 25°C	Staphylococcus aureus	Zn2+

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Release 2023.1 (January 2023)