KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.004 | - |
sisomicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.01 | - |
neomycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.016 | - |
tobramycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.024 | - |
dibekacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.03 | - |
kanamycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.032 | - |
amikacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.036 | - |
arbekacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.044 | - |
isepamicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.07 | - |
netilmicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Stenotrophomonas maltophilia | V5XKM9 | - |
- |
Stenotrophomonas maltophilia IOMTU250 | V5XKM9 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + amikacin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetylamikacin | - |
? | |
acetyl-CoA + amikacin | - |
Stenotrophomonas maltophilia IOMTU250 | CoA + 6'-N-acetylamikacin | - |
? | |
acetyl-CoA + arbekacin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetylarbekacin | - |
? | |
acetyl-CoA + arbekacin | - |
Stenotrophomonas maltophilia IOMTU250 | CoA + 6'-N-acetylarbekacin | - |
? | |
acetyl-CoA + dibekacin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetyldibekacin | - |
? | |
acetyl-CoA + dibekacin | - |
Stenotrophomonas maltophilia IOMTU250 | CoA + 6'-N-acetyldibekacin | - |
? | |
acetyl-CoA + isepamicin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetylisepamicin | - |
? | |
acetyl-CoA + kanamycin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetylkanamycin | - |
? | |
acetyl-CoA + kanamycin | - |
Stenotrophomonas maltophilia IOMTU250 | CoA + 6'-N-acetylkanamycin | - |
? | |
acetyl-CoA + neomycin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetylneomycin | - |
? | |
acetyl-CoA + netilmicin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetylnetilmicin | - |
? | |
acetyl-CoA + sisomicin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetylsisomicin | - |
? | |
acetyl-CoA + tobramycin | - |
Stenotrophomonas maltophilia | CoA + 6'-N-acetyltobramycin | - |
? | |
additional information | no substrates: apramycin, gentamicin, or lividomycin | Stenotrophomonas maltophilia | ? | - |
? | |
additional information | no substrates: apramycin, gentamicin, or lividomycin | Stenotrophomonas maltophilia IOMTU250 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AAC(6)-Iak | - |
Stenotrophomonas maltophilia |
aminoglycoside N(6')-acetyltransferase type 1 | - |
Stenotrophomonas maltophilia |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.04 | - |
kanamycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.05 | - |
isepamicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.08 | - |
tobramycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.11 | - |
amikacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.16 | - |
sisomicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.25 | - |
dibekacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.3 | - |
netilmicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.32 | - |
neomycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
0.57 | - |
arbekacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia |
General Information | Comment | Organism |
---|---|---|
physiological function | Escherichia coli transformed with a plasmid containing aac(6')-Iak exhibits decreased susceptibility to arbekacin, dibekacin, neomycin, netilmicin, sisomicin, and tobramycin | Stenotrophomonas maltophilia |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1 | - |
kanamycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
1 | - |
isepamicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
4 | - |
amikacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
4 | - |
netilmicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
6 | - |
tobramycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
10 | - |
dibekacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
16 | - |
arbekacin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
34 | - |
neomycin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia | |
38 | - |
sisomicin | pH not specified in the publication, temperature not specified in the publication | Stenotrophomonas maltophilia |