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Literature summary for 2.3.1.82 extracted from

  • Gao, F.; Yan, X.; Auclair, K.
    Synthesis of a phosphonate-linked aminoglycoside-coenzyme a bisubstrate and use in mechanistic studies of an enzyme involved in aminoglycoside resistance (2009), Chemistry, 15, 2064-2070.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine aminoglycoside N-6'-acetyltransferases are important determinants of antibiotic resistance Enterococcus faecium

Inhibitors

Inhibitors Comment Organism Structure
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(3-sulfanylpropanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(4-sulfanylbutanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(5-sulfanylpentanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(sulfanylacetyl)amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(2-sulfanylethyl)sulfonyl]amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2-deoxy-6-O-[methoxy(2-sulfanylethyl)phosphoryl]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium

Organism

Organism UniProt Comment Textmining
Enterococcus faecium
-
-
-

Synonyms

Synonyms Comment Organism
AAC(6')
-
Enterococcus faecium
AAC(6')-Ii
-
Enterococcus faecium
aminoglycoside N-6'-acetyltransferase
-
Enterococcus faecium
aminoglycoside N-6'-acetyltransferase Ii
-
Enterococcus faecium

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Enterococcus faecium

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.00004
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(3-sulfanylpropanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
0.00008
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(sulfanylacetyl)amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
0.00016
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(4-sulfanylbutanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
0.0016
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[[(2-sulfanylethyl)sulfonyl]amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
0.002
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2-deoxy-6-O-[methoxy(2-sulfanylethyl)phosphoryl]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium
0.008
-
(1R,2R,3S,4R,6S)-4,6-diamino-2,3-dihydroxycyclohexyl 2-amino-2,6-dideoxy-6-[(5-sulfanylpentanoyl)amino]-alpha-D-glucopyranoside-S-CoA
-
Enterococcus faecium