Application | Comment | Organism |
---|---|---|
analysis | direct method to assay HGSNAT enzymatic activity using fluorescent BODIPY-glucosamine, i.e. 1-[4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl-glycylamino]-beta-D-glucosamine, as a substrate | Homo sapiens |
medicine | direct method to assay HGSNAT enzymatic activity using fluorescent BODIPY-glucosamine, i.e. 1-[4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl-glycylamino]-beta-D-glucosamine, as a substrate. Cultured fibroblasts of mucopolysaccharidosis III type C patients show a profound deficiency of HGSNAT activity as compared to normal controls as well as to mucopolysaccharidosis III type A and D patients known to have normal HGSNAT activity | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
transfection of COS-7 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
D-glucosamine | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q68CP4 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 1-[4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl-glycylamino]-beta-D-glucosamine | i.e. fluorescent BODIPY-glucosamine | Homo sapiens | CoA + 1-[4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl-glycylamino]-N-acetyl-beta-D-glucosamine | - |
? | |
acetyl-CoA + 4-methylumbelliferyl-beta-D-glucosaminide | - |
Homo sapiens | CoA + 4-methylumbelliferyl-N-acetyl-beta-D-glucosaminide | - |
? | |
acetyl-CoA + heparan sulfate alpha-D-glucosaminide | - |
Homo sapiens | CoA + heparan sulfate N-acetyl-alpha-D-glucosaminide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
HGSNAT | - |
Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.26 | - |
D-glucosamine | substrate 1-[4,4-difluoro-5,7-dimethyl-4-bora-3a,4a-diaza-s-indacene-3-propionyl-glycylamino]-beta-D-glucosamine, pH 6.5, 37°C | Homo sapiens | |
0.28 | - |
D-glucosamine | substrate 4-methylumbelliferyl-beta-D-glucosaminide, pH 6.5, 37°C | Homo sapiens |