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Literature summary for 2.3.1.7 extracted from
- Purification and properties of carnitine acetyltransferase from human liver (1990), Eur. J. Biochem., 189, 539-546.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | - |
Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ca2+ | - |
Homo sapiens |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0213 | - |
acetyl-CoA | - |
Homo sapiens | |
| 0.028 | - |
propionyl-CoA | - |
Homo sapiens | |
| 0.0435 | - |
butyryl-CoA | - |
Homo sapiens | |
| 0.0503 | - |
octanoyl-CoA | - |
Homo sapiens | |
| 0.0549 | - |
hexanoyl-CoA | - |
Homo sapiens | |
| 0.064 | - |
decanoyl-CoA | - |
Homo sapiens | |
| 0.086 | - |
carnitine | cosubstrate propionyl-CoA | Homo sapiens | |
| 0.097 | - |
carnitine | cosubstrate acetyl-CoA | Homo sapiens | |
| 0.12 | - |
carnitine | cosubstrate hexanoyl-CoA | Homo sapiens | |
| 0.148 | - |
carnitine | cosubstrate octanoyl-CoA | Homo sapiens | |
| 0.152 | - |
carnitine | cosubstrate butyryl-CoA | Homo sapiens | |
| 0.42 | - |
acetylcarnitine | - |
Homo sapiens | |
| 0.58 | - |
carnitine | cosubstrate decanoyl-CoA | Homo sapiens | |
| 0.65 | - |
propionylcarnitine | - |
Homo sapiens | |
| 1.39 | - |
octanoylcarnitine | - |
Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | membrane-bound | Homo sapiens | 5739 | - |
| mitochondrion | membrane-bound | Rattus norvegicus | 5739 | - |
| peroxisome | - |
Homo sapiens | 5777 | - |
| peroxisome | - |
Rattus norvegicus | 5777 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 60500 | - |
gel filtration | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | Homo sapiens | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Rattus norvegicus | - |
O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | Sus scrofa | - |
O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Homo sapiens | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Rattus norvegicus | - |
acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | Sus scrofa | - |
acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | Homo sapiens | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Rattus norvegicus | - |
acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | Sus scrofa | - |
acyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Homo sapiens | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Rattus norvegicus | - |
acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | Sus scrofa | - |
acetyl-CoA + carnitine | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human | - |
| Rattus norvegicus | - |
rat | - |
| Sus scrofa | - |
pig | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | - |
Rattus norvegicus | - |
| brown adipose tissue | - |
Rattus norvegicus | - |
| fibroblast | - |
Homo sapiens | - |
| heart | - |
Homo sapiens | - |
| heart | - |
Rattus norvegicus | - |
| heart | - |
Sus scrofa | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| kidney | - |
Sus scrofa | - |
| liver | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| nervous system | - |
Rattus norvegicus | - |
| testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 78.75 | - |
- |
Homo sapiens |
Storage Stability
| Storage Stability | Organism |
|---|---|
| -20°C, when stored in 50% glycerol, maintains its activity unaltered for several months | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + carnitine | - |
Homo sapiens | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + carnitine | - |
Sus scrofa | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Homo sapiens | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | O-acetylcarnitine + CoASH | - |
r | |
| acetyl-CoA + L-(-)carnitine | - |
Sus scrofa | O-acetylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Homo sapiens | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Rattus norvegicus | acylcarnitine + CoASH | - |
r | |
| acyl-CoA + carnitine | - |
Sus scrofa | acylcarnitine + CoASH | - |
r | |
| acylcarnitine + CoASH | - |
Homo sapiens | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Rattus norvegicus | acyl-CoA + carnitine | - |
r | |
| acylcarnitine + CoASH | - |
Sus scrofa | acyl-CoA + carnitine | - |
r | |
| decanoyl-CoA + carnitine | - |
Rattus norvegicus | decanoylcarnitine + CoASH | - |
r | |
| decanoyl-CoA + carnitine | - |
Sus scrofa | decanoylcarnitine + CoASH | - |
r | |
| decanoylcarnitine + CoASH | - |
Homo sapiens | decanoyl-CoA + carnitine | - |
r | |
| decanoylcarnitine + CoASH | - |
Rattus norvegicus | decanoyl-CoA + carnitine | - |
r | |
| decanoylcarnitine + CoASH | - |
Sus scrofa | decanoyl-CoA + carnitine | - |
r | |
| hexanoyl-CoA + L-carnitine | - |
Homo sapiens | CoA + O-hexanoyl-L-carnitine | - |
? | |
| additional information | palmitoyl-CoA is no substrate | Homo sapiens | ? | - |
? | |
| n-butyryl-CoA + carnitine | - |
Homo sapiens | n-butyrylcarnitine + CoASH | - |
r | |
| n-butyryl-CoA + carnitine | - |
Rattus norvegicus | n-butyrylcarnitine + CoASH | - |
r | |
| n-butyrylcarnitine + CoASH | - |
Homo sapiens | n-butyryl-CoA + carnitine | - |
r | |
| n-butyrylcarnitine + CoASH | - |
Rattus norvegicus | n-butyryl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Homo sapiens | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Sus scrofa | acetyl-CoA + L-(-)carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Homo sapiens | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Rattus norvegicus | acetyl-CoA + carnitine | - |
r | |
| O-acetylcarnitine + CoASH | - |
Sus scrofa | acetyl-CoA + carnitine | - |
r | |
| octanoyl-CoA + carnitine | - |
Homo sapiens | octanoylcarnitine + CoASH | - |
r | |
| octanoyl-CoA + carnitine | - |
Rattus norvegicus | octanoylcarnitine + CoASH | - |
r | |
| octanoylcarnitine + CoASH | - |
Homo sapiens | octanoyl-CoA + carnitine | - |
r | |
| octanoylcarnitine + CoASH | - |
Rattus norvegicus | octanoyl-CoA + carnitine | - |
r | |
| propionyl-CoA + L-(-)carnitine | - |
Homo sapiens | propionylcarnitine + CoASH | - |
r | |
| propionyl-CoA + L-(-)carnitine | - |
Rattus norvegicus | propionylcarnitine + CoASH | - |
r | |
| propionylcarnitine + CoASH | - |
Homo sapiens | propionyl-CoA + L-(-)carnitine | - |
r | |
| propionylcarnitine + CoASH | - |
Rattus norvegicus | propionyl-CoA + L-(-)carnitine | - |
r | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | - |
Rattus norvegicus |
| monomer | 1 * 60500, SDS-PAGE | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.7 | - |
- |
Homo sapiens |
| 8.7 | - |
- |
Sus scrofa |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 10 | - |
Homo sapiens |
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