Cloned (Comment) | Organism |
---|---|
gene ehv050, DNA and amino acid sequence determination and analysis, functional expression of HA-tagged enzyme in Saccharmoyces cerevisiae endoplasmic reticulum, when the two subunits of the yeast SPT are thus expressed, the single-chain chimera is functional and displays a different substrate preference, independently expressed domains of the viral SPT reassemble into an active protein, overview | Coccolithovirus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
endoplasmic reticulum | - |
Coccolithovirus | 5783 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Coccolithovirus | the viral single-chain enzyme might form multiprotein complexes in vivo with functions different from the monomer | ? | - |
? | |
myristoyl-CoA + L-serine | Coccolithovirus | SPT is the first and rate-limiting enzyme of sphingolipid biosynthesis | CoA + 2-amino-1-hydroxyhexadecan-3-one + CO2 | - |
? | |
palmitoyl-CoA + L-serine | Coccolithovirus | SPT is the first and rate-limiting enzyme of sphingolipid biosynthesis | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Coccolithovirus | - |
infects the globally important marine calcifying microalga Emiliania huxleyi, gene ehv050 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the viral single-chain enzyme might form multiprotein complexes in vivo with functions different from the monomer | Coccolithovirus | ? | - |
? | |
additional information | acyl-CoA substrate specificity, overview | Coccolithovirus | ? | - |
? | |
myristoyl-CoA + L-serine | SPT is the first and rate-limiting enzyme of sphingolipid biosynthesis | Coccolithovirus | CoA + 2-amino-1-hydroxyhexadecan-3-one + CO2 | - |
? | |
myristoyl-CoA + L-serine | the viral enzyme exhibits preference for myristoyl-CoA rather than palmitoyl-CoA | Coccolithovirus | CoA + 2-amino-1-hydroxyhexadecan-3-one + CO2 | - |
? | |
palmitoyl-CoA + L-serine | SPT is the first and rate-limiting enzyme of sphingolipid biosynthesis | Coccolithovirus | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? | |
palmitoyl-CoA + L-serine | the viral enzyme exhibits preference for myristoyl-CoA rather than palmitoyl-CoA | Coccolithovirus | CoA + 3-dehydro-D-sphinganine + CO2 | - |
? |
Subunits | Comment | Organism |
---|---|---|
monomer | single-chain enzyme, domain structure, overview | Coccolithovirus |
Synonyms | Comment | Organism |
---|---|---|
serine palmitoyltransferase | - |
Coccolithovirus |
SPT | - |
Coccolithovirus |