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Literature summary for 2.3.1.5 extracted from
- Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis (2007), Pharmacogenet. Genomics, 17, 181-188.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a polymorphic homologue of human NAT2 is characterized in the rhesus macaque, to facilitate investigations of the postulated involvement of this isoenzyme in the toxicogenetics of endometriosis | Macaca mulatta |
| medicine | to better understand the possible relationship between the NAT2 gene and endometriosis, its homologue in the resus macaque is characterized | Macaca mulatta |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in CHO cells | Macaca mulatta |
| expressed in Escherichia coli and in CHO cells | Macaca mulatta |
| for expression in mammalian cells | Macaca mulatta |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C624T | synonymous polymorphism | Macaca mulatta |
| G691A | nonsynonymous polymorphism, causing a V231I substitution | Macaca mulatta |
| recombinant (MACMU)NAT2 protein | analysed for the ability to acetylate NAT substrates and bind anti-NAT antibodies | Macaca mulatta |
| V231I | polymorphic allele Nat2*2 found in rhesus macaque, differentiated by one nonsynonymous G691A polymorphism, resulting in a Val231Ile substitution. Mutant shows differences in activity with most substrates (pmol/min/luminescence unit): 183 (p-anisidine), 4 (procainamide), 3 (sulphamethazine), 11 (5-aminosalicylate), 3 (p-aminobenzoic acid) | Macaca mulatta |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Macaca mulatta | - |
- |
- |
| Macaca mulatta | Q7YRG5 | polymorphic allele Nat2*1 | - |
| Macaca mulatta | Q7YRG5 | polymorphic allele Nat2*2 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| blood | - |
Macaca mulatta | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
specific activities of various substrates (pmol/min/luminescence unit): 183 (p-anisidine), 4 (procainamide), 3 (sulphamethazine), 11 (5-aminosalicylate), 3 (p-aminobenzoic acid) | Macaca mulatta |
| additional information | - |
specific activities of various substrates (pmol/min/luminescence unit): 197 (p-anisidine), 18 (procainamide), 12 (sulphamethazine), 2 (5-aminosalicylate), 0 (p-aminobenzoic acid) | Macaca mulatta |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetyl-CoA + 4-aminobenzoic acid | - |
Macaca mulatta | CoA + N-acetyl-4-aminobenzoic acid | - |
? |  |
| acetyl-CoA + 5-aminosalicylate | - |
Macaca mulatta | CoA + 5-acetylamino-2-hydroxybenzoate | - |
? | |
| acetyl-CoA + 5-aminosalicylate | - |
Macaca mulatta | CoA + N-acetyl-5-aminosalicylate | - |
? | |
| acetyl-CoA + 5-aminosalicylate | - |
Macaca mulatta | ? | - |
? | |
| acetyl-CoA + p-aminobenzoic acid | poor activity | Macaca mulatta | CoA + N-acetyl-p-aminobenzoic acid | - |
? | |
| acetyl-CoA + p-aminobenzoic acid | - |
Macaca mulatta | ? | - |
? | |
| acetyl-CoA + p-anisidine | - |
Macaca mulatta | ? | - |
? | |
| acetyl-CoA + p-anisidine | - |
Macaca mulatta | CoA + p-methoxyacetanilide | - |
? | |
| acetyl-CoA + p-anisidine | - |
Macaca mulatta | CoA + N-acetylanisidine | - |
? | |
| acetyl-CoA + procainamide | - |
Macaca mulatta | CoA + N-acetylprocainamide | - |
? | |
| acetyl-CoA + procainamide | - |
Macaca mulatta | ? | - |
? | |
| acetyl-CoA + procainamide | lower activity | Macaca mulatta | CoA + N-acetyl-2-procainamide | - |
? | |
| acetyl-CoA + sulfamethazine | - |
Macaca mulatta | ? | - |
? | |
| acetyl-CoA + sulphamethazine | - |
Macaca mulatta | CoA + N-acetylsulphamethazine | - |
? | |
| sulphamethazine + acetyl-CoA | - |
Macaca mulatta | N-[4-[(4,6-dimethylpyrimidin-2-yl)sulfamoyl]phenyl]acetamide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| arylamine N-acetyltransferase | - |
Macaca mulatta |
| arylamine N-acetyltransferase 2 | - |
Macaca mulatta |
| NAT2 | - |
Macaca mulatta |
| NAT2*1 | polymorphic allele Nat2*1, differentiated by one synonymous C624T polymorphism | Macaca mulatta |
| NAT2*2 | polymorphic allele Nat2*2, differentiated by one nonsynonymous G691A polymorphism, resulting in a Val231Ile substitution | Macaca mulatta |
| rhesus NAT2 | - |
Macaca mulatta |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Macaca mulatta |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at | Macaca mulatta |
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