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Literature summary for 2.3.1.5 extracted from

  • Oda, Y.; Watanabe, T.; Terao, Y.; Nukaya, H.; Wakabayashi, K.
    Genotoxic activation of 2-phenylbenzotriazole-type compounds by human cytochrome P4501A1 and N-acetyltransferase expressed in Salmonella typhimurium umu strains (2008), Mutat. Res., 654, 52-57.
    View publication on PubMed
Search for more literature for 2.3.1.5

Application

Application Comment Organism
molecular biology results demonstrate that human P4501A1 and NATs (NAT1 and NAT2) contribute significantly to the activation of PBTA-type compounds to genotoxic metabolites that induce umuC gene expression in Salmonella typhimurium tester strains Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
over-expressed in Salmonella typhimurium umu strain Homo sapiens

Protein Variants

Protein Variants Comment Organism
additional information genotoxic activation of PBTA derivatives using Salmonella typhimurium NM6001 (human NAT1-expressing strain), Salmonella typhimurium NM6002 (human NAT2-expressing strain), and Salmonella typhimurium NM6000 (O-acetyltransferase-deficient parent strain) in the presence of S9 mix is determined. PBTA-4 shows almost similar sensitivity in the NAT1-expressing strain and the NAT2-expressing strain, although NAT2-expressing strain exhibits relatively higher sensitivity to PBTA-6, PBTA-7, and PBTA-8 than NAT1-expressing strain. The NM6000 strain is not found to be sensitive to all of these chemicals The results support the view that O-acetylation by human NAT1 and NAT2 enzymes is involved in the genotoxic activation of PBTA compounds Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase 1
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 Homo sapiens
arylamine N-acetyltransferase 2
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 Homo sapiens
NAT1
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 Homo sapiens
NAT2
-
 Homo sapiens