Application | Comment | Organism |
---|---|---|
medicine | results suggest that care should be taken to prevent the development of isoniazid-induced hepatic disorder in patients who have the NAT2 SA phenotype, a high concentration of rifampicin and who carry the GST M1 null genotype | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | genotypes of drug-metabolizing enzymes (NAT2, CYP2E15*B, CYP2E1*6, Glutathione-S-transferase (GST) M1 and GST T1) involved in isoniazid metabolism and the serum concentrations of isoniazid and its metabolites in 129 tuberculosis patients are investigated. Acetylating pathway of isoniazid to acetyl isoniazid tends to shift to the hydrolytic pathway generating hydrazine with the increase of mutant alleles in NAT2 gene | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
arylamine N-acetyltransferase 2 | - |
Homo sapiens |
NAT2 | - |
Homo sapiens |