Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.3.1.5 extracted from

  • Wakefield, L.; Robinson, J.; Long, H.; Ibbitt, J.C.; Cooke, S.; Hurst, H.C.; Sim, E.
    Arylamine N-acetyltransferase 1 expression in breast cancer cell lines: a potential marker in estrogen receptor-positive tumors (2008), Genes Chromosomes Cancer, 47, 118-126.
    View publication on PubMed

Application

Application Comment Organism
medicine the data pave the way for investigating NAT1 transcripts as candidate prognostic markers in ER-positive breast cancer Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
CAL-51 cell
-
Homo sapiens
-
CAL-51 cell breast cancer cell line, estrogen receptor (ER)-negative, expression below detection limits in Western blot analysis Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
MCF-7 cell breast cancer cell line, estrogen receptor (ER)-positive, expression below detection limits in Western blot analysis Homo sapiens
-
MDA-MB-231 cell
-
Homo sapiens
-
MDA-MB-231 cell breast cancer cell line, estrogen receptor (ER)-negative, expression below detection limits in Western blot analysis Homo sapiens
-
MDA-MB-436 cell
-
Homo sapiens
-
MDA-MB-436 cell breast cancer cell line, estrogen receptor (ER)-negative, expression below detection limits in Western blot analysis Homo sapiens
-
MDA-MB-453 cell
-
Homo sapiens
-
MDA-MB-453 cell breast cancer cell line, estrogen receptor (ER)-negative, expression below detection limits in Western blot analysis Homo sapiens
-
T-47D cell
-
Homo sapiens
-
T-47D cell breast cancer cell line, estrogen receptor (ER)-positive, expression below detection limits in Western blot analysis Homo sapiens
-
ZR-75-1 cell
-
Homo sapiens
-
ZR-75-1 cell breast cancer cell line, estrogen receptor (ER)-positive, strong expression in Western blot analysis Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.0001
-
breast cancer cell line Cal51c, estrogen receptor (ER)-negative Homo sapiens
0.0001
-
CAL-51 cell Homo sapiens
0.0002
-
breast cancer cell line MDA-MB-231, estrogen receptor (ER)-negative Homo sapiens
0.0002
-
MDA-MB-231 cell Homo sapiens
0.0007
-
breast cancer cell line MDA-MB-436, estrogen receptor (ER)-negative Homo sapiens
0.0007
-
MDA-MB-436 cell Homo sapiens
0.001
-
breast cancer cell line MCF-7, estrogen receptor (ER)-positive Homo sapiens
0.0018
-
MCF-7 cell Homo sapiens
0.0021
-
breast cancer cell line MDA-MB-453, estrogen receptor (ER)-negative Homo sapiens
0.0021
-
MDA-MB-453 cell Homo sapiens
0.005
-
breast cancer cell line T47D, estrogen receptor (ER)-positive Homo sapiens
0.0054
-
T-47D cell Homo sapiens
0.202
-
breast cancer cell line ZR-75-1, estrogen receptor (ER)-positive Homo sapiens
0.2022
-
ZR-75-1 cell Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-CoA + p-aminobenzoic acid in vitro N-acetylation assay Homo sapiens CoA + N-acetyl-4-aminobenzoic acid
-
?
acetyl-CoA + p-aminobenzoic acid
-
Homo sapiens CoA + N-acetyl-aminobenzoic acid
-
?

Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase 1
-
Homo sapiens
arylamine N-acetyltransferase I
-
Homo sapiens
NAT
-
Homo sapiens
NAT1
-
Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens
7.5
-
in vitro N-acetylation assay Homo sapiens

Cofactor

Cofactor Comment Organism Structure
acetyl-CoA
-
Homo sapiens