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Literature summary for 2.3.1.5 extracted from

  • Possuelo, L.G.; Castelan, J.A.; de Brito, T.C.; Ribeiro, A.W.; Cafrune, P.I.; Picon, P.D.; Santos, A.R.; Teixeira, R.L.; Gregianini, T.S.; Hutz, M.H.; Rossetti, M.L.; Zaha, A.
    Association of slow N-acetyltransferase 2 profile and anti-TB drug-induced hepatotoxicity in patients from Southern Brazil (2008), Eur. J. Clin. Pharmacol., 64, 673-681.
    View publication on PubMed
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Application

Application Comment Organism
medicine present study examines an association of slow N-acetyltransferase 2 profile caused by classical N-acetylation polymorphism and anti-tuberculosis drug-induced hepatotoxicity in patients from Southern Brazil. 254 Brazilian tuberculosis patients using isoniazid (INH), rifampicin (RMP), and pirazinamide (PZA) are tested in a prospective cohort study. Results demonstrate that HIV-positive patients that have the slow acetylation profile are significantly associated with a higher risk of developing hepatotoxicity due to anti-tuberculosis drugs Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P11245
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Synonyms

Synonyms Comment Organism
arylamine N-acetyltransferase 2
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 Homo sapiens
NAT2
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 Homo sapiens