Application | Comment | Organism |
---|---|---|
medicine | the internationally recommended dosage of isoniazid for patients with two active NAT2 alleles in order to achieve appropriate antituberculous efficiency should be increased | Homo sapiens |
medicine | to estimate an optimal dosage for isoniazid (INH) RA-type patients (patients with two active NAT2 alleles due to genetic polymorphisms) a dose escalation study in healthy male volunteers is conducted carrying mutation NAT2*4/*4. In RA-type subjects, the pharmacokinetic parameters appear to lack linearity with the increased dose of isoniazid. It is proposed that the proper daily dose for RA-type patients is 1.5times higher than that currently recommended | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C190T | NAT2 single nucleotide polymorphism | Homo sapiens |
C481T | NAT2 single nucleotide polymorphism | Homo sapiens |
G191A | NAT2 single nucleotide polymorphism | Homo sapiens |
G590A | NAT2 single nucleotide polymorphism | Homo sapiens |
G857A | NAT2 single nucleotide polymorphism | Homo sapiens |
T341C | NAT2 single nucleotide polymorphism | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + isoniazid | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
arylamine N-acetyltransferase 2 | - |
Homo sapiens |
NAT2 | - |
Homo sapiens |