Protein Variants | Comment | Organism |
---|---|---|
A54V | activity with 2-aminofluorene is about 10% of the wild-type activity | Homo sapiens |
D251G | activity with 2-aminofluorene is about 15% of the wild-type activity | Homo sapiens |
F202L | activity with 2-aminofluorene is about 20% of the wild-type activity | Homo sapiens |
I238T | activity with 2-aminofluorene is about 30% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value | Homo sapiens |
K185N | activity with 2-aminofluorene is about 35% of the wild-type activity, the KM-value for 2-aminofluorene is 1.5fold higher than the wild-type value | Homo sapiens |
L181A | activity with 2-aminofluorene is about 80% of the wild-type activity | Homo sapiens |
L194R | activity with 2-aminofluorene is about 30% of the wild-type activity | Homo sapiens |
L40H | activity with 2-aminofluorene is about 5% of the wild-type activity | Homo sapiens |
M205V | activity with 2-aminofluorene is about 40% of the wild-type activity | Homo sapiens |
N172I | activity with 2-aminofluorene is about 20% of the wild-type activity, the KM-value for 2-aminofluorene is 3.6fold higher than the wild-type value | Homo sapiens |
N245I | activity with 2-aminofluorene is about 85% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value | Homo sapiens |
P96L | activity with 2-aminofluorene is slightly higher than wild-type activity | Homo sapiens |
Q226R | activity with 2-aminofluorene is about 15% of the wild-type activity | Homo sapiens |
T198A | activity with 2-aminofluorene is about 50% of the wild-type activity | Homo sapiens |
T207S | activity with 2-aminofluorene is slightly higher than wild-type activity | Homo sapiens |
V146A | activity with 2-aminofluorene is about 50% of the wild-type activity | Homo sapiens |
W77R | activity with 2-aminofluorene is about 25% of the wild-type activity, the KM-value for 2-aminofluorene is 1.3fold higher than the wild-type value | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.238 | - |
2-Aminofluorene | wild-type enzyme | Homo sapiens | |
0.298 | - |
2-Aminofluorene | mutant enzyme I238T | Homo sapiens | |
0.301 | - |
2-Aminofluorene | mutant enzyme 245I | Homo sapiens | |
0.304 | - |
2-Aminofluorene | mutant enzyme W77R | Homo sapiens | |
0.367 | - |
2-Aminofluorene | mutant enzyme K185N | Homo sapiens | |
0.857 | - |
2-Aminofluorene | mutant enzyme N172I | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
acetyl-CoA + 2-aminofluorene | - |
Homo sapiens | CoA + 2-acetylaminofluorene | - |
? |
Synonyms | Comment | Organism |
---|---|---|
NAT2 | - |
Homo sapiens |