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Literature summary for 2.3.1.46 extracted from
- Biological properties and mode of action of clavams (1987), Arch. Microbiol., 147, 315-320.
General Stability
| General Stability | Organism |
|---|---|
| glycerol, 30% w/v, stabilizes during purification | Escherichia coli |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| hydroxyethylclavam | oxygen analogue beta-lactam antibiotic | Escherichia coli |  |
| L-methionine | feed-back inhibition | Escherichia coli | |
| additional information | overview, competitive antagonism of peptides against enzyme inhibition by valclavam; overview, inhibition of several fungi and procaryotes by valclavam | Escherichia coli | |
| S-adenosyl-L-methionine | feed-back inhibition | Escherichia coli | |
| Valclavam | oxygen analogue beta-lactam antibiotic, complete inhibition at 0.2 mM | Escherichia coli | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Escherichia coli |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| succinyl-CoA + L-homoserine | - |
Escherichia coli | CoA + O-succinyl-L-homoserine | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00025 | - |
hydroxyethylclavam | dissociation constant of enzyme-substrate-inhibitor complex | Escherichia coli | |
| 0.00083 | - |
Valclavam | - |
Escherichia coli | |
| 0.00089 | - |
Valclavam | dissociation constant of enzyme-substrate-inhibitor complex | Escherichia coli | |
| 0.00092 | - |
hydroxyethylclavam | - |
Escherichia coli | |
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