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Literature summary for 2.3.1.41 extracted from

  • Zhang, L.; Joshi, A.K.; Hofmann, J.; Schweizer, E.; Smith, S.
    Cloning, expression, and characterization of the human mitochondrial beta-ketoacyl synthase. Complementation of the yeast CEM1 knock-out strain (2005), J. Biol. Chem., 280, 12422-12429.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
cerulenin 50% inhibition at 0.2 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0018
-
decanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
0.0019
-
hexanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
0.0039
-
butanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
0.0095
-
dodecanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
0.0109
-
octanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
0.05
-
acetyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
0.0508
-
myristoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
45800
-
x * 45800, SDS-PAGE, recombinant protein without N-terminal targeting sequence, with His-tag Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens important role in generation of the lipoic acid precursor octanoyl-acyl-carrier protein ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
expression in Escherichia coli, without N-terminal targeting sequence
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification mitochondrial targeting sequence of 38 residues Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
brain low level Homo sapiens
-
heart most abundant Homo sapiens
-
kidney
-
Homo sapiens
-
liver
-
Homo sapiens
-
lung low level Homo sapiens
-
placenta low level Homo sapiens
-
skeletal muscle most abundant Homo sapiens
-
spleen low level Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
acetyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Homo sapiens 3-oxobutanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
butanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Homo sapiens 3-oxohexanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
decanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Homo sapiens dodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
dodecanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Homo sapiens 3-oxotetradecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
hexanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Homo sapiens 3-oxooctanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
additional information important role in generation of the lipoic acid precursor octanoyl-acyl-carrier protein Homo sapiens ?
-
?
additional information preference for acyl-[acyl-carrier protein] in decreasing order: C12, C10, C6, C8, C4, C2, C14, C16 Homo sapiens ?
-
?
myristoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Homo sapiens 3-oxohexadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
octanoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Homo sapiens 3-oxodecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?
palmitoyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein]
-
Homo sapiens 3-oxooctadecanoyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]
-
?

Subunits

Subunits Comment Organism
? x * 45800, SDS-PAGE, recombinant protein without N-terminal targeting sequence, with His-tag Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
6
-
myristoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
66
-
octanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
91.2
-
butanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
303
-
dodecanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
353
-
hexanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens
551
-
decanoyl-[acyl-carrier protein] pH 6.8, 37°C Homo sapiens