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Literature summary for 2.3.1.35 extracted from

  • Hao, N.; Mu, J.; Hu, N.; Xu, S.; Yan, M.; Li, Y.; Guo, K.; Xu, L.
    Improvement of L-citrulline production in Corynebacterium glutamicum by ornithine acetyltransferase (2015), J. Ind. Microbiol. Biotechnol., 42, 307-313.
    View publication on PubMed
Search for more literature for 2.3.1.35

Cloned(Commentary)

Cloned (Comment) Organism
gene argJ, recombinant overexpression in Corynebacterium glutamicum strain ATCC 13032 Corynebacterium glutamicum

Protein Variants

Protein Variants Comment Organism
additional information L-citrulline overproduction in Corynebacterium glutamicum engineered strain correlates with expression levels of ArgJ, which plays a vital role in the L-citrulline biosynthesis Corynebacterium glutamicum

Inhibitors

Inhibitors Comment Organism Structure
L-citrulline
-
 Corynebacterium glutamicum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
N2-acetyl-L-ornithine + L-glutamate Corynebacterium glutamicum
-
 L-ornithine + N-acetyl-L-glutamate
-
 ?
N2-acetyl-L-ornithine + L-glutamate Corynebacterium glutamicum ATCC 13032
-
 L-ornithine + N-acetyl-L-glutamate
-
 ?

Organism

Organism UniProt Comment Textmining
Corynebacterium glutamicum Q59280 gene argJ
-
Corynebacterium glutamicum ATCC 13032 Q59280 gene argJ
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N2-acetyl-L-ornithine + L-glutamate
-
 Corynebacterium glutamicum L-ornithine + N-acetyl-L-glutamate
-
 ?
N2-acetyl-L-ornithine + L-glutamate
-
 Corynebacterium glutamicum ATCC 13032 L-ornithine + N-acetyl-L-glutamate
-
 ?

Synonyms

Synonyms Comment Organism
argJ
-
 Corynebacterium glutamicum
OATase
-
 Corynebacterium glutamicum
ornithine acetyltransferase
-
 Corynebacterium glutamicum

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Corynebacterium glutamicum

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Corynebacterium glutamicum

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
30
-
 pH 7.5, 37°C Corynebacterium glutamicum L-citrulline

General Information

General Information Comment Organism
metabolism ArgJ plays a vital role in the L-citrulline biosynthesis. The enzyme exerts feedback inhibition on N-acetylglutamate synthase, pathway overview Corynebacterium glutamicum