Literature summary for 2.3.1.29 extracted from

McGilvray, D.; Morris, J.G.
Utilization of L-threonine by a species of Arthrobacter. A novel catabolic role for aminoacetone synthase (1969), Biochem. J., 112, 657-671.

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Activating Compound

Activating Compound	Comment	Organism	Structure
iodoacetamide	increases yield of aminoacetone by 50%	Arthrobacter sp.

Inhibitors

Inhibitors	Comment	Organism	Structure
CoA	-	Arthrobacter sp.
glutathione	-	Arthrobacter sp.
L-cysteine	-	Arthrobacter sp.
additional information	no inhibition by DTNB; not: glycine	Arthrobacter sp.

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
acetyl-CoA + glycine	Arthrobacter sp.	involved in L-threonine catabolism, inducible	CoA + 2-amino-3-oxobutanoate	-	?

Organism

Organism	UniProt	Comment	Textmining
Arthrobacter sp.	-	grown on L-threonine	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
additional information	-	-	Arthrobacter sp.

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
acetyl-CoA + glycine	-	Arthrobacter sp.	CoA + 2-amino-3-oxobutanoate	spontaneous decarboxylation to aminoacetone	?
acetyl-CoA + glycine	involved in L-threonine catabolism, inducible	Arthrobacter sp.	CoA + 2-amino-3-oxobutanoate	-	?

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Release 2023.1 (January 2023)