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Literature summary for 2.3.1.28 extracted from
- A chromosomal chloramphenicol acetyltransferase determinant from a probiotic strain of Bacillus clausii (2009), FEMS Microbiol. Lett., 296, 185-189.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| acetyl-CoA | - |
Alkalihalobacillus clausii |  |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | probiotic mixture for the prevention of gastrointestinal side effects due to oral antibiotic therapy, no resistance transfer to Enterococcus faecalis JH2-2, Enterococcus faecium HM1070 (both resistant to rifampin and fusidic acid) and Bacillus subtilis UCN19 (resistant to ciprofloxacin) in mating experiments | Alkalihalobacillus clausii |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| PCR-amplification, electrotransformation into Escherichia coli DH10B to test for chloramphenicol inactivation with Micrococcus lutes ATCC 9341 as indicator organism | Alkalihalobacillus clausii |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 26660 | - |
predicted from sequence analysis, 347 bp, 228 amino acid protein, chromosomal location | Alkalihalobacillus clausii |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chloramphenicol + acetyl-CoA | Alkalihalobacillus clausii | - |
chloramphenicol 3-acetate + CoA | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Alkalihalobacillus clausii | Q6XD71 | chloramphenicol resistant strains OC, NR, SIN, and T, susceptible control strains DSM8716, ATCC 21536, and ATCC 21537 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chloramphenicol + acetyl-CoA | - |
Alkalihalobacillus clausii | chloramphenicol 3-acetate + CoA | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CAT | catBcl gene, strain SIN | Alkalihalobacillus clausii |
| chloramphenicol acetyltransferase | - |
Alkalihalobacillus clausii |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | chloramphenicol resistance | Alkalihalobacillus clausii |
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Release 2023.1 (January 2023)
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